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GenomicsChromatinized PKC-q directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells
Epithelial to mesenchymal transition (EMT) is activated during cancer invasion and metastasis, enriches for cancer stem cells (CSCs), and contributes to therapeutic resistance and disease recurrence. Signal transduction kinases play a pivotal role as chromatin-anchored proteins in eukaryotes. Here w...
ORGANISM(S): Homo sapiens 
2014-06-22 | E-GEOD-53320 | biostudies-arrayexpress
TranscriptomicsThe role of PKCtheta in Epithelial to Mesenchymal Transistion
Epithelial to mesenchymal transition (EMT) is activated during cancer invasion and metastasis, enriches for cancer stem cells (CSCs), and contributes to therapeutic resistance and disease recurrence. Signal transduction kinases play a pivotal role as chromatin-anchored proteins in eukaryotes. Here w...
ORGANISM(S): Homo sapiens 
2014-06-22 | E-GEOD-53267 | biostudies-arrayexpress
TranscriptomicsPKC Activation Induces Inflammatory Response and Cell Death in Human Bronchial Epithelial Cells
A variety of airborne pathogens can induce inflammatory responses in airway epithelial cells, which is a crucial component of host defence. However, excessive inflammatory responses and chronic inflammation also contribute to different diseases in the respiratory system. We hypothesized that the ac...
ORGANISM(S): Homo sapiens 
2013-05-27 | E-GEOD-44747 | biostudies-arrayexpress
GenomicsRegulation of inducible genes in epithelial to mesenchymal transition by chromatinized PKC-theta
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-06-22 | E-GEOD-53335 | biostudies-arrayexpress
TranscriptomicsInduction of Senescence in Diterpene Ester-Treated Melanoma Cells via PKC-dependent Hyperactivation of the MAPK Pathway
The diterpene ester PEP005 is a novel anticancer agent that activates PKC and cures subcutaneous murine melanoma by topical application. We now describe the in vitro cytostatic effects of PEP005 and the diterpene ester TPA, observed in 20% of human melanoma cell lines. Primary cultures of normal h...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-3484 | biostudies-arrayexpress
ProteomicsLarge-scale in vitro kinase assay with FLNc d23-24 and PKC alpha
Large-scale in vitro kinase assay with human and murine FLNc and its site mutants and PKC alpha.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2017-01-02 | PXD003185 | Pride
Lc-ms In vitro kinase assay Flnc Pkc alpha 
TranscriptomicsPKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized not only by neuronal loss and synaptic dysfunction but also by emerging evidence of oligodendrocyte and myelin pathology. Amyloid-β (Aβ), a hallmark of AD, disrupts oligodendrocyte homeostasis through mechanisms that remain poorly understood. Here, we invest...
ORGANISM(S): Mus musculus 
2025-12-31 | E-MTAB-16400 | biostudies-arrayexpress
TranscriptomicsGene expression profile changes in PKC-inhibitor-pretreated HT1080 cells cells after TLR3 stimulation
TLR3 stimulation by extracellular dsRNA (e.g. polyIC) induces expression of numerous genes. The inhibition of PKC by Go6976 prior to TLR3 stimulation leads to an ablation of expression of IRF-3-dependent genes. Total RNA extracted from HT1080 cells with or without 1 h pretreatment with 5 uM Go6976, ...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-43217 | biostudies-arrayexpress
ProteomicsPKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
Leucine-rich-repeat-kinase 1 (LRRK1) and its homologue LRRK2 are multidomain kinases possessing an atypical ROC-CORA-CORB containing GTPase domain and phosphorylate distinct Rab proteins. LRRK1 loss of function mutations cause the bone disorder osteosclerotic metaphyseal dysplasia, whereas LRRK2 mis...
ORGANISM(S): Homo sapiens (Human) 
2022-09-02 | PXD034420 | Pride
Rab7a Lrrk1 Pkc Phosphorylation 
TranscriptomicsProtein Kinase C Mediated Extraembryonic Endoderm Differentiation of Human Embryonic Stem Cells
Unlike mouse embryonic stem (ES) cells, which are closely related to the inner cell mass, human ES cells appear to be more closely related to the later primitive ectoderm. For example, human ES cells and primitive ectoderm share a common epithelial morphology, growth factor requirements, and the po...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-33180 | biostudies-arrayexpress
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