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ProteomicsPhosphoproteomics to uncover phosphorylation substrates changes when serine/threonine protein kinase PknA and PknB depletion
The Mycobacterium tuberculosis eukaryotic-like serine/threonine protein kinase (STPKs) PknA and PknB regulate several processes required for cell growth, both kinase have been found to be and can be investigated by using the conditional mutant. In the present study, we created the M. tuberculosis ki...
ORGANISM(S): Mycobacterium tuberculosis C StG4006 
2020-05-27 | PXD015197 | Pride
Mycobacterium tuberculosis  serine/threonine protein kinase (stpks) pkna and pknb  phosphoproteomics 
UnknownProtein kinases PknA and PknB independently and coordinately regulate essential Mycobacterium tuberculosis physiologies and antimicrobial susceptibility.
Not available
S-EPMC7164672 | biostudies-literature
UnknownPhosphorylation of Mycobacterium tuberculosis Ser/Thr phosphatase by PknA and PknB.
Not available
S-EPMC3052367 | biostudies-literature
UnknownMtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions.
Not available
S-EPMC5733270 | biostudies-literature
UnknownGenetic and biochemical analysis of the serine/threonine protein kinases PknA, PknB, PknG and PknL of Corynebacterium glutamicum: evidence for non-essentiality and for phosphorylation of OdhI and FtsZ by multiple kinases.
Not available
S-EPMC2784874 | biostudies-literature
ProteomicsPhosphorylation of CFP10 modulates Mycobacterium tuberculosis virulence
Virulence effectors secreted by Mycobacterium tuberculosis (Mtb) help subvert host immune mechanisms and, therefore, are critical for establishing infection and pathogenesis. However, knowledge in terms of signaling mechanisms that modulate the secretion of virulence factors is sparse. We performed ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2023-09-22 | PXD045586 | Pride
Cfp10 Secretion Virulence Pkna Tuberculosis Pknb Phosphorylation Esat6 
TranscriptomicsMultisystems analysis of Mycobacterium tuberculosis reveals kinase-dependent remodeling of the pathogen-environment interface
Tuberculosis is the leading killer among infectious diseases worldwide. Increasing multi-drug resistance has prompted new approaches for tuberculosis drug development, including targeted inhibition of virulence determinants and of signaling cascades that control many downstream pathways. We used a m...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2018-03-08 | GSE110508 | GEO
UnknownProbing the Highly Disparate Dual Inhibitory Mechanisms of Novel Quinazoline Derivatives against Mycobacterium tuberculosis Protein Kinases A and B.
Not available
S-EPMC7571077 | biostudies-literature
UnknownPhosphorylation of mycobacterial phosphodiesterase by eukaryotic-type Ser/Thr kinase controls its two distinct and mutually exclusive functionalities.
Not available
S-EPMC5655513 | biostudies-literature
UnknownMycobacterium tuberculosis MtrB sensor kinase interactions with FtsI and Wag31 proteins reveal a role for MtrB distinct from that regulating MtrA activities.
Not available
S-EPMC4248866 | biostudies-literature
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