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ProteomicsProteomic analysis of ARVC rat with PKP2 mutation heart
To investigate the changes in sodium channel proteins in ARVC rats with PKP2 gene mutations, we performed proteomic analysis on the hearts of WT and PKP2 rats.
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD066271 | Pride
Heart Proteome Pkp2 Rat Arvc 
GenomicsExploring the downstream genes of PKP2
Exploring the downstream genes of PKP2
PRJNA590035 | ENA
GenomicsTo explore the downstream genes of PKP2
To explore the downstream genes of PKP2
PRJNA655489 | ENA
ProteomicsDesmosomal protein degradation accompanied by desmosomal and adherens junctions protein disarray as underlying causes of PKP2 driven arrhythmogenic cardiomyopathy
Arrhythmogenic cardiomyopathy (ACM) is an inherited progressive cardiomyopathy. The pathophysiological events are well understood, yet the underlying molecular mechanisms remain undefined. Here, we created a novel research platform comprising of patient originated hiPSC-derived cardiomyocytes bearin...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-18 | PXD020605 | Pride
Proteomics Pkp2 Desmosomal protein degradation Arrhythmogenic cardiomyopahty 
GenomicsPKP2 orchestrates OXPHOS expression in cardiomyocytes via a PGC-1a dependent mechanism
PKP2 orchestrates OXPHOS expression in cardiomyocytes via a PGC-1a dependent mechanism
PRJNA1269633 | ENA
TranscriptomicsTo explore the downstream genes of PKP2
To explore the downstream genes of PKP2,we performed RNA-seq to screen after overexpression of PKP2 in A549 cells.
ORGANISM(S): Homo sapiens 
2023-08-05 | GSE155759 | GEO
UnknownAAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy.
Not available
S-EPMC10948840 | biostudies-literature
Proteomicsarrythmogenic right ventricular acrdiomayopathy (PKP2-cko in mice and Human biopsies)
Summary: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disorder. It is classified as the second most common cause of unexpected sudden death by cardiac arrest in the young. ARVC has devastating psychosocial consequences, especially as many patients are young adults, ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-11-04 | PXD025523 | Pride
Cardiovascular protemics Tmt Heart failure Arvc 
UnknownPleiotropic Phenotypes Associated With PKP2 Variants.
Not available
S-EPMC6305316 | biostudies-literature
GenomicsTNYA0016: Time-dependent transcriptional effects of PKP2 mRNA knockdown in wild-type human iPSC-CMs
TNYA0016: Time-dependent transcriptional effects of PKP2 mRNA knockdown in wild-type human iPSC-CMs
PRJNA1064598 | ENA
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