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TranscriptomicsTranscription profiling of right ventricule from arrhythmogenic heterozygous plakoglobin deficient mice undergone endurance training to identify transcriptional responses to training.
Endurance training accelerated development of right ventricular dysfunction and arrhythmias in plakoglobin+/- mice. Histology and electron microscopy did not identify right ventricular abnormalities. To identify differences in the transcriptional response to training gene expression profiling was pe...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-4120 | biostudies-arrayexpress
ProteomicsA signaling hub of insulin receptor dystrophin glycoprotein complex and plakoglobin regulates muscle size
Signaling through the insulin receptor governs central physiological functions related to cell growth and metabolism. Here we show by tandem native protein complex purification approach and super-resolution STED microscopy that insulin receptor activity requires association with the fundamental stru...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-19 | PXD016989 | Pride
Dystrophin Plakoglobin Insulin receptor 
GenomicsPlakoglobin is a mechanoresponsive regulator of naïve pluripotency
Plakoglobin is a mechanoresponsive regulator of naïve pluripotency
PRJNA811439 | ENA
TranscriptomicsPlakoglobin is a mechanoresponsive regulator of naïve pluripotency
Biomechanical cues are instrumental in guiding embryonic development and cell differentiation. Understanding how these physical stimuli translate into transcriptional programs could provide insight into mechanisms underlying mammalian pre-implantation development. Here, we explore this by exerting m...
ORGANISM(S): Mus musculus 
2023-05-10 | GSE197643 | GEO
Transcriptomicsgamma-catenin (junction plakoglobin, Jup) dependent signals mediate the progression of BCR-ABL1+ B-ALL
The BCR-ABL1 translocation product is the cause of Chronic Myeloid Leukemia (CML) and of a significant fraction of adult-onset B-Acute Lymphoblastic Leukemia (B-ALL) cases. Here we identify an essential role for gamma-catenin (junction plakoglobin) in B lineage restricted cells for the progression o...
ORGANISM(S): Mus musculus 
2014-02-08 | E-GEOD-54793 | biostudies-arrayexpress
UnknownPlakoglobin is a mechanoresponsive regulator of naive pluripotency.
Not available
S-EPMC10329048 | biostudies-literature
UnknownA novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy.
Not available
S-EPMC2265660 | biostudies-literature
UnknownPlakoglobin suppresses epithelial proliferation and hair growth in vivo.
Not available
S-EPMC2175163 | biostudies-literature
UnknownCell-cell contact preserves cell viability via plakoglobin.
Not available
S-EPMC3203941 | biostudies-literature
UnknownA signaling hub of insulin receptor, dystrophin glycoprotein complex and plakoglobin regulates muscle size.
Not available
S-EPMC7070008 | biostudies-literature
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