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GenomicsPlakophilin 1 enhances MYC expression to promote squamous cell lung cancer
Plakophilin 1 enhances MYC expression to promote squamous cell lung cancer
PRJNA417944 | ENA
ProteomicsGFP-Trap analysis of PKP1-WT-GFP and PKP3-WT-GFP in keratinocytes
To identify putative interaction partners for Plakophilin (PKP) 1 and 3 that might be involved in the regulation of UV-induced signaling pathways, we used PKP1 knockout (KO) keratinocytes (KCs) expressing either PKP1-WT-EGFP or PKP3-WT-EGFP. Prior to GFP-trap immunoprecipitations, these cells were l...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-22 | PXD065254 | Pride
Plakophilin 3 Keratinocytes Gfp-trap Uv-irradiation Plakophilin 1 
GenomicsPlakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases
Plakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases
PRJNA1279987 | ENA
TranscriptomicsPlakophilin 1 enhances MYC expression to promote squamous cell lung cancer
Plakophilin 1 (PKP1) is a component of desmosomes. Although desmosome function loss has been associated with increased cell migration and pro-oncogenic activity, we previously observed PKP1 overexpression in squamous cell lung cancer (SqCLC). We developed in vitro and in vivo functional models of PK...
ORGANISM(S): Homo sapiens 
2020-05-10 | GSE106770 | GEO
UnknownPlakophilin-1 protects keratinocytes from pemphigus vulgaris IgG by forming calcium-independent desmosomes.
Not available
S-EPMC3961504 | biostudies-literature
UnknownA plakophilin-1 gene mutation in an egyptian family with ectodermal dysplasia-skin fragility syndrome.
Not available
S-EPMC4281574 | biostudies-literature
TranscriptomicsPlakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases
The innate immune response is a first line of defense that allows a rapid reaction to pathogens as well as molecules released from damaged cells. It relies on pathogen-sensing receptors, many of which are nucleic acid-binding proteins, including RNA helicases. Plakophilin 1 (PKP1) is a desmosomal pr...
ORGANISM(S): Homo sapiens 
2026-08-20 | GSE300261 | GEO
UnknownDeficient plakophilin-1 expression due to a mutation in PKP1 causes ectodermal dysplasia-skin fragility syndrome in Chesapeake Bay retriever dogs.
Not available
S-EPMC3284538 | biostudies-literature
UnknownPlakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast Differentiation.
Not available
S-EPMC4806907 | biostudies-literature
UnknownThe desmosomal plaque proteins of the plakophilin family.
Not available
S-EPMC2879962 | biostudies-literature
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