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TranscriptomicsMechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis
Data from clinical studies, cell culture, and animal models implicate the urokinase (uPA)/Plasminogen (Plg) system in the development of atherosclerosis and aneurysms. However, the mechanisms through which uPA/Plg stimulate these diseases are not yet defined. We used genetically modified, atherosc...
ORGANISM(S): Mus musculus 
2011-05-03 | E-GEOD-29028 | biostudies-arrayexpress
ProteomicsPlasminogen proteoform profiling
Plasminogen, the zymogen of plasmin, is a glycoprotein involved in fibrinolysis and a wide variety of other physiological processes. Plasminogen dysregulation has been implicated in a range of diseases. Classically, human plasminogen is categorized into two types based on the presence (type I) or ab...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2024-05-24 | PXD042225 | Pride
Plasminogen serum ptm 
TranscriptomicsSynergy between plasminogen activator inhibitor-1 and Snail in tumoral migration
Snail, a family of transcriptional repressors implicated in cell movement, has been correlated with tumour invasivity. The Plasminogen Activation system (PAs), including urokinase (uPA), its receptor (uPAR), and its inhibitor (PAI-1), also plays a key role in cancer invasion and metastasis, either t...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10395 | biostudies-arrayexpress
TranscriptomicsAge and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Recombinant tissue-type plasminogen activator (tPA) is the fibrinolytic drug of choice to treat stroke patients. However, a growing body of evidence indicates that besides its beneficial thrombolytic role, tPA can also have a deleterious effect on the ischaemic brain. Although ageing influences stro...
ORGANISM(S): Mus musculus 
2009-08-23 | E-GEOD-9004 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling after bile duct ligation identifies PAI-1 as a contributor to cholestatic injury in mice.
Extrahepatic cholestasis leads to complex injury and repair processes that result in bile infarct formation, neutrophil infiltration, cholangiocyte and hepatocyte proliferation, extracellular matrix remodeling, and fibrosis. To identify early molecular mechanisms of injury and repair after bile duct...
ORGANISM(S): Mus musculus 
2011-06-09 | E-GEOD-29776 | biostudies-arrayexpress
ProteomicsAE-MS to profile SLO-human plasma protein interactome landscape; HDX-MS and XL-MS to study protein interaction and dynamics of PLG-SLO
Group A Streptococcus is known to exploit the human fibrinolysis system, particularly by targeting the plasminogen/plasmin pathway through redundant pathomechanisms. In this study, we began with affinity-enrichment mass spectrometry to map the interaction landscape between streptolysin O and human p...
ORGANISM(S): Homo sapiens (Human) Streptococcus pyogenes MGAS315 
2024-10-17 | PXD051261 | Pride
Ae-ms Human Streptolysin o Streptococcus pyogenes Xl-ms Hdx-ms Plasminogen Lc-ms/ms 
ProteomicsProtease activity profiling of ovarian clear cell carcinoma
Ovarian clear cell carcinoma (OCCC) is an understudied poor prognosis subtype of ovarian cancer lacking in effective molecularly targeted therapies; efforts to define drivers of OCCC malignancy may lead to new therapeutic targets and approaches. Among potential targets are secreted proteases, enzyme...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-07 | MSV000087385 | MassIVE
ProteomicsHDXMS of urokinase plasminogen activator
HDX-MS of urokinase plasminogen activator in single-chain vs two-chain forms
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-28 | MSV000090611 | MassIVE
TranscriptomicsTranscriptomic analysis of Urokinase plasminogen activator receptor silenced MDA-MB-231 breast cancer cells, stimulated with radiation.
Urokinase plasminogen activator receptor (PLAUR) is a GPI anchored extracellular surface receptor, playing a major role in remodeling of the extracellular matrix. It has the ability to interact with a variety of co-receptors for intracellular signaling. Over-expression of PLAUR is observed in many p...
ORGANISM(S): Homo sapiens 
2019-01-31 | E-MTAB-5298 | biostudies-arrayexpress
GenomicsPlasminogen lipid cargo drives macrophage TLR2 activation independent of protease activity
Plasminogen lipid cargo drives macrophage TLR2 activation independent of protease activity
PRJNA1396608 | ENA
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