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TranscriptomicsRegulation of Puf2 Expression is Critical for Plasmodium Sporozoite Development and Maintenance of Sporozoite Transmissibility
MalariaM-bM-^@M-^Ys cycle of infection requires parasite transmission between a mosquito vector and a vertebrate host. Plasmodium regulates transmission by translationally repressing specific mRNAs until their products are needed. We demonstrate that the Plasmodium yoelii Pumilio-FBF family member P...
ORGANISM(S): Plasmodium yoelii yoelii 17XNL 
2012-10-27 | E-GEOD-41873 | biostudies-arrayexpress
MetabolomicsMetabolic balancing by miR-276 shapes the mosquito reproductive cycle and Plasmodium falciparum development
The blood-feeding behavior of Anopheles females delivers essential nutrients for egg development and drives parasite transmission between humans. Plasmodium growth is adapted to the vector reproductive cycle, but how changes in the reproductive cycle impact parasite development remains unclear. Here...
2021-11-03 | MTBLS1282 | MetaboLights
MetabolomicsMaHPIC Experiment 07A and 07B: Quantitative Metabolomics from Macaca fascicularis infected with Plasmodium knowlesi sporozoites to produce and integrate clinical, hematological, parasitological, omics, telemetric and histopathological measures of acute primary infection
E07 was originally planned and implemented prior to E06. The E07 cohort was inoculated with freshly dissected P. knowlesi sporozoites on 11/01/16. However, for unexplained reasons blood-stage parasitemias did not occur. Consequently, the E07 cohort was reinoculated with cryopreserved P. kn...
2019-01-11 | MTBLS822 | MetaboLights
MetabolomicsMaHPIC Experiment 06: Quantitative Metabolomics from Macaca mulatta infected with Plasmodium knowlesi sporozoites to produce and integrate clinical, hematological, parasitological, omics, telemetric and histopathological measures of acute primary infection
Telemetry devices (DSI, model L11) with blood pressure sensors and electrocardiogram (ECG) leads were surgically implanted in four malaria-naive male rhesus macaques (Macaca mulatta), approximately five years of age. After a resting period of two weeks, physiological data that include activit...
2019-01-14 | MTBLS824 | MetaboLights
MetabolomicsMaHPIC Experiment 30: Metabolomics from the pilot experiment for Macaca mulatta infected with Plasmodium knowlesi Malayan strain sporozoites to produce and integrate clinical, hematological, parasitological, omics, telemetric and histopathological measures of acute primary infection
Telemetry devices (DSI, model L11) with blood pressure sensors and electrocardiogram (ECG) leads were surgically implanted in two malaria-naive male rhesus macaques (Macaca mulatta), approximately three years of age. After a resting period of two weeks, physiological data that include activit...
2017-10-22 | MTBLS536 | MetaboLights
MetabolomicsMaHPIC Experiment 30: Quantitative Metabolomics from the pilot experiment for Macaca mulatta infected with Plasmodium knowlesi Malayan strain sporozoites to produce and integrate clinical, hematological, parasitological, omics, telemetric and histopathological measures of acute primary infection
Telemetry devices (DSI, model L11) with blood pressure sensors and electrocardiogram (ECG) leads were surgically implanted in two malaria-naive male rhesus macaques (Macaca mulatta), approximately three years of age. After a resting period of two weeks, physiological data that include activit...
2019-01-11 | MTBLS821 | MetaboLights
ProteomicsAnalysis of Plasmodium sporozoites collected from mosquito saliva
Plasmodium sporozoites are injected, in addition to saliva, into animal hosts when a female Anopheles mosquito takes a blood meal. The molecular components of saliva that interact with Plasmodium during this process are poorly characterized. Here we collected Plasmodium sporozoites directly from sal...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) Plasmodium berghei ANKA Anopheles gambiae (African malaria mosquito) Anopheles stephensi (Asian malaria mosquito) 
2018-10-18 | PXD010121 | Pride
Plasmodium Malaria Saliva Anopheles gambiae Sporozoites 
MetabolomicsMaHPIC Experiment HuC - Metabolomics of plasma samples from human volunteers infected with Plasmodium vivax
Project Description:
The Malaria Host-Pathogen Interaction Center (MaHPIC) is a transdisciplinary malaria systems biology research program initially supported by an NIH/NIAID contract (HHSN272201200031C, 2012-2017; see http://w...
2018-06-19 | MTBLS665 | MetaboLights
ProteomicsProteomic analysis of Plasmodium yoelii oocyst sporozoites
Proteomic analysis of Plasmodium yoelii oocyst sporozoites
ORGANISM(S): Plasmodium yoelii yoelii 17XNL 
2019-10-02 | PXD009729 | Pride
Oocyst sporozoites Plasmodium yoelii 
ProteomicsIn-depth proteomic analysis of Plasmodium berghei sporozoites using trapped ion mobility spectrometry with parallel accumulation-serial fragmentation
We took advantage of a novel highly sensitive timsTOF PRO mass spectrometer, based on trapped ion mobility spectrometry with parallel accumulation-serial fragmentation. Combined with three alternative methods for sporozoite purification, this approach allowed us to identify the deep proteome of P. b...
ORGANISM(S): Plasmodium berghei ANKA 
2021-02-11 | PXD022735 | Pride
Malaria Mass spectrometry Sporozoites Proteome Plasmodium berghei Timstof pro 
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