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ProteomicsSystematic evaluation of blood contamination in nanoparticle-based plasma proteomics
Circulating blood proteomics enables minimally invasive biomarker discovery. Nanoparticle-based circulating plasma proteomics studies have reported varying number of proteins (ca 2000-7000), but it’s unclear whether higher protein number is more informative. Here, we first develop OmniProt – a silic...
ORGANISM(S): Homo sapiens (Human) 
2025-12-12 | PXD068107 | Pride
Coagulation contamination Lung cancer  biomarkers Edta tube Erythrocyte contamination Nanoparticle Sodium citrate tube Lithium heparin tube Platelet contamination Plasma proteomics 
TranscriptomicsRNA-Seq of human platelet polyA-mRNA from a normal male
RNA-sequencing analysis of human platelet polyA-mRNA from a normal male. The goal of this experiment was to identify genes expressed in unstimulated circulating platelets.
ORGANISM(S): Homo sapiens 
2012-06-30 | E-MTAB-715 | biostudies-arrayexpress
TranscriptomicsAKS1-S3
RNA-sequencing analysis of human platelet rRNA-depleted total RNA from two normal males and one female. The goal of this experiment was to identify genes expressed in unstimulated circulating platelets. Data from platelet polyA-mRNA has also been deposited at ArrayExpress, under accession number E-M...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-MTAB-1846 | biostudies-arrayexpress
GenomicsIdentification and elimination of the platelet-derived transcripts contamination in circulating tumor cell single-cell RNA-seq study
Identification and elimination of the platelet-derived transcripts contamination in circulating tumor cell single-cell RNA-seq study
PRJNA560887 | ENA
TranscriptomicsIdentification and elimination of the platelet-derived transcripts contamination in circulating tumor cell single-cell RNA-seq study
Single-cell RNA sequencing (scRNA-seq) holds great potential to revolutionize our understanding of cancer biology by discovering biomarkers and biological functions from circulating tumor cells (CTCs). However, the contamination from blood cells is one of the main challenges in CTC studies. Through ...
ORGANISM(S): Homo sapiens 
2020-04-18 | GSE135992 | GEO
GenomicsPlatelet transcriptome and high platelet turnover in sepsis
Impact of high platelet turnover on the platelet transcriptome: Results from platelet RNA-sequencing in patients with sepsis
PRJEB45262 | ENA
TranscriptomicsDifferences in platelet miRNA profiles between patients with coronary artery disease and healthy controls.
Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies. Platelets play a major role, not only in the process of acute thrombosis during plaque rupture, but also in the formation of atherosclerosis itself. ...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-59421 | biostudies-arrayexpress
ProteomicsCharacterisation of Platelet Releasate Proteome in Relapsing-Remitting Multiple Sclerosis Reveals Dysregulation of Inflammatory Signalling and Extracellular Vesicle Dynamics
Multiple Sclerosis is an inflammatory neurodegenerative disease characterised by blood-brain barrier dysfunction and leukocyte infiltration into the central nervous system. Platelets are best known for their contributions to haemostasis, however upon activation platelets release an abundance of solu...
ORGANISM(S): Homo sapiens (Human) 
2025-01-09 | PXD050479 | Pride
Multiple sclerosis Platelet releasate 
ProteomicsA phosphoproteomic analysis of platelets in severe obesity uncovers platelet reactivity and signaling pathways alterations
Objective: Obesity is associated with a pro-inflammatory and pro-thrombotic state that supports atherosclerosis progression. The goal of this study was to gain insights into the phosphorylation events related to platelet reactivity in obesity and identify platelet biomarkers and altered activation p...
ORGANISM(S): Homo sapiens (Human) 
2022-02-23 | PXD020204 | Pride
Obesity Biomarkers Platelets Quantitative phosphoproteomics 
ProteomicsComprehensive analysis of platelet glycoprotein Ibα glycosylation.
Background: Platelet glycoprotein (GP) Ibα is the major ligand-binding subunit of the GPIb-IX-V complex that binds von Willebrand Factor (VWF). GPIbα is heavily glycosylated, and its glycans have been proposed to play key roles in platelet clearance, VWF binding, and as target antigens in immune thr...
ORGANISM(S): Homo sapiens (Human) 
2023-02-09 | PXD035030 | Pride
Human Platelets Glycoproteins 
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