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MetabolomicsDifferential Metabolomic Biomarkers Analysis of Apheresis Platelet Storage Based on Machine Learning Models

Platelet storage lesion (PSL) is a critical factor limiting the efficacy of platelet transfusion. Although hypothermic (4°C) storage is considered beneficial for maintaining platelet function, the underlying mechanisms of systemic metabolic reprogramming remain incompletely understood. This study...

2026-07-27 | MTBLS15165 | MetaboLights
MetabolomicsMulti-Omic Analysis and Platelet Function Distinguish Treatment Responses to Hydroxytyrosol in Cardiovascular Risk
Many polyphenols have been recognized for their antioxidant and health benefits. The present study attempted, for the first time, to determine the effects of daily oral intake of β-cyclodextrin-encapsulated hydroxytyrosol (HT) on plasma platelet reactivity and proteomic and metabolomic profiles of p...
2025-06-30 | MTBLS12336 | MetaboLights
MetabolomicsUntargeted Metabolomics of Mouse Platelet Pellets by LC-MS/MS
In this study, platelet pellets were isolated from mouse peripheral blood through gradient centrifugation to obtain high-purity platelet samples. Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based untargeted metabolomics was performed to comprehensively profile the global metabolic chan...
2026-08-04 | MTBLS15244 | MetaboLights
MetabolomicsRisk assessment with gut microbiome and metabolite markers in NAFLD development
A growing body of evidence suggests interplay between the gut microbiota and the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, the role of the gut microbiome in early detection of NAFLD is unclear. Prospective studies are necessary for identifying reliable, microbiome markers fo...
2022-07-11 | MTBLS2615 | MetaboLights
MetabolomicsClinical features and Multiomics Profiles Indicate Coagulation and Platelet Dysfunction as Key Pathological Pathways in COVID-19 Viral Sepsis
Background: The role of viral infections as a mediator of systemic immune dysfunction leading to sepsis has received limited attention compared to the bacterial pathogens. The COVID-19 pandemic and the increased cases of sepsis in the absence of known bacterial pathogens have highlighted the clinica...
2025-12-05 | MTBLS9664 | MetaboLights
ProteomicsEarly-stage cancer biomarkers uncovered in the blood platelet proteome
Platelets play an important role in tumor growth and at the same time, platelet characteristics are affected by cancer presence. Therefore, we investigated whether the platelet proteome can be used as a source for biomarkers of early-stage cancer. Patients with early-stage lung (n=8) and head of pan...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-29 | MSV000082867 | MassIVE
TranscriptomicsCharacterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction.
Recent technological advances have made transcriptome sequencing (RNA-seq) possible in cells with low RNA copy number including platelets. Resulting studies have used RNA-seq in platelets isolated from healthy individuals to characterize the platelet transcriptome. However, platelets, possibly throu...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-65705 | biostudies-arrayexpress
MetabolomicsInhibition of stress resilience and adult hippocampal neurogenesis by platelet-derived LPA16:0 in anxiety

Anxiety is an aggravating comorbidity of many psychiatric disorders that is often underdiagnosed and undertreated, and little is known on the mechanisms underlying its regulation. Here, we find that serum LPA16:0 abundance increases with trait anxiety in both humans and mice; while high LPA16:0 l...

2026-02-05 | MTBLS13589 | MetaboLights
ProteomicsIdentification of SEC61B as a novel regulator of calcium flux and platelet hyperactivity in diabetes mellitus
Platelet hyperactivity contributes to increased cardiovascular thrombosis in diabetes. Intracellular and released proteins control platelet activity however there are limited proteomic studies of the diabetic platelet. We isolated platelets from 34 patients without, and 42 patients with type 2 diabe...
ORGANISM(S): Homo sapiens (Human) 
2025-04-19 | PXD049321 | Pride
Sec61b Calcium Er stress Diabetes Translocon Platelet 
TranscriptomicsClass prediction models of thrombocytosis using genetic biomarkers
Using custom spotted oligonucelotide platelet-focused arrays, platelet samples were compared. 48 health controls, 23 reactive thrombocytosis (RT) and 24 essential thrombocythemia (ET) samples were compared. An 11-biomarker gene subset was identified that discriminated among the three cohorts with 86...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-12295 | biostudies-arrayexpress
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