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MetabolomicsDifferential Metabolomic Biomarkers Analysis of Apheresis Platelet Storage Based on Machine Learning Models

Platelet storage lesion (PSL) is a critical factor limiting the efficacy of platelet transfusion. Although hypothermic (4°C) storage is considered beneficial for maintaining platelet function, the underlying mechanisms of systemic metabolic reprogramming remain incompletely understood. This study...

2026-07-27 | MTBLS15165 | MetaboLights
ProteomicsPlatelet proteomics profiling in transfusion adverse events
Blood platelets destined for transfusion release panoply of molecules during preparation and storage. The leukoreduction process made the transfusion safer but did not completely abolish the adverse events. The rationale is to study the proteome profile of platelet components SDA-PC (platelet pellet...
ORGANISM(S): Homo sapiens (Human) 
2019-02-13 | PXD008886 | Pride
Platelet concentrates (pc) Proteomics Transfusion Single donor apheresis-pc (sda-pc) 
ProteomicsPlatelet proteomics profiling in transfusion adverse events, part 2
Blood platelets destined for transfusion release panoply of molecules during preparation and storage. The leukoreduction process made the transfusion safer but did not completely abolish the adverse events. The rationale is to study the proteome profile of platelet components PPC (platelet pellets) ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-13 | PXD003510 | Pride
Platelet concentrates (pc) Proteomics Buffy-coat-derived pooled pc (ppc) Transfusion 
GenomicsEvidence of Listeria monocytogenes infection following platelet transfusion
Evidence of Listeria monocytogenes infection following platelet transfusion
PRJEB62146 | ENA
ProteomicsPlatelet transfusion-induced changes in plasma profiles
Mechanisms underlying variability in patient’s responses to platelet transfusions are not fully understood. To characterize platelet transfusion induced changes on plasma proteins, we used plasma proteomics to study the effect of 1) autologous platelet transfusions in healthy volunteers in absence a...
ORGANISM(S): Homo sapiens (Human) 
2025-09-17 | PXD060882 | Pride
Platelet Plasma Dia Label-free Transfusion Proteomics 
ProteomicsDeciphering changes to human platelet proteome and degradome during storage before transfusion
Proteases, and specifically metalloproteinases, have been linked to the loss of platelet function during storage before transfusion, albeit the mechanism remains unknown. We used a dedicated N-terminomics technique, multiplex iTRAQ-TAILS (Terminal Amine Isotope Labeling of Substrates), to characteri...
ORGANISM(S): Homo sapiens (Human) 
2014-10-24 | PXD000906 | Pride
Platelets Metalloproteinases Degradome Proteases Tails Human Ls-msms 
ProteomicsA Comprehensive Proteomics Study on Platelet Concentrates: Platelet Proteome, Storage Time and Mirasol Pathogen Reduction Technology
Platelet concentrates (PCs) represent a blood transfusion product with a major concern for safety as their storage temperature (20-24ºC) allows bacterial growth, and their maximum storage time period (less than a week) precludes complete microbiological testing. Pathogen inactivation technologies (P...
ORGANISM(S): Homo sapiens (Human) 
2018-03-23 | PXD008119 | Pride
Platelet function tests Storage time Platelet transfusion Pathogen inactivation technologies Blood safety Proteomics 
ProteomicsProteomic analysis of extracellular vesicles derived from platelet concentrates treated with Mirasol® identifies biomarkers of platelet storage lesion
In blood banks, platelets are stored until 7 days after a pathogen reduction technology (PRT) treatment, Mirasol® (vitamin B2 plus UVB light) in the present case. The storage time under these conditions may have an impact on platelets and their releasate leading to potential adverse reactions follow...
ORGANISM(S): Homo sapiens (Human) 
2022-09-30 | PXD014694 | Pride
Extracellular vesicles  platelet concentrates  transfusion medicine  swath 
UnknownPlatelet transfusion induces transfusion-associated circulatory overload in rats with myocardial infarction.
Not available
S-EPMC12227162 | biostudies-literature
GenomicsComplement Inhibition Using Eculizumab to Overcome Platelet Transfusion Refractoriness in Patients with Severe Thrombocytopenia
Complement Inhibition Using Eculizumab to Overcome Platelet Transfusion Refractoriness in Patients with Severe Thrombocytopenia
PRJNA938237 | ENA
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