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TranscriptomicsExpression data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines.
Cisplatin and carboplatin are the primary first-line therapies for the treatment of ovarian cancer. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, subsequently resulting in a poor long-term prognosis. To model the onset of drug resista...
ORGANISM(S): Homo sapiens 
2009-04-17 | E-GEOD-15372 | biostudies-arrayexpress
TranscriptomicsGenomic Multivariate Predictors of Response to Adjuvant Chemotherapy in Ovarian Carcinoma: Predicting Platinum Resistance
Purpose: Despite advances in radical surgery and chemotherapy delivery, ovarian cancer is the most lethal gynecologic malignancy. Most of these patients are treated with platinum-based chemotherapies, but there is no biomarker model to guide their responses to these therapeutic agents. We have d...
ORGANISM(S): Homo sapiens 
2012-08-21 | E-GEOD-30161 | biostudies-arrayexpress
TranscriptomicsInduction of 1C Aldoketoreductases and Other Drug Dose-dependent Genes Upon Acquisition of Anthracycline Resistance
Recent studies have suggested that elevated expression of aldoketoreductase (AKR) 1C1 or 1C2 in tumour cells is associated with increased resistance to DNA damaging agents such as cisplatin and doxorubicin. However, it has not been shown whether selection of tumour cells for resistance to DNA-damag...
ORGANISM(S): Homo sapiens 
2008-07-16 | E-GEOD-12115 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A540 non small cell carcinoma cell lines reveals synergy between PPARgamma ligands and platinum-based drugs in cancer
PPARγ is a member of the nuclear receptor family for which agonist ligands have anti-growth effects. However, clinical studies using PPARγ ligands as a monotherapy failed to show a beneficial effect. Here we have studied the effects of PPARγ activation with chemotherapeutic agents in current us...
ORGANISM(S): Homo sapiens 
2009-04-30 | E-GEOD-7035 | biostudies-arrayexpress
ProteomicsIdentification of proteins deregulated by platinum-based chemotherapy as novel biomarkers and therapeutic targets in non-small cell lung cancer
Platinum-based chemotherapy remains the cornerstone of treatment for most people with non-small cell lung cancer (NSCLC), either as adjuvant therapy in combination with a second cytotoxic agent or in combination with immunotherapy. Resistance to therapy, either in the form of primary refractory dise...
ORGANISM(S): Homo Sapiens 
PXD024209 | panorama
TranscriptomicsPharmacogenomic Approach for the Identification of Novel Determinants of Resistance to Oxaliplatin in Colon Cancer
Oxaliplatin is a member of the family of Pt-containing chemotherapeutic agents that also include cisplatin (CDDP) and carboplatin. OXA is distinguished from these two older drugs by its different spectrum of activity both in preclinical models and in clinical trials. It is the only platinum analogue...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10405 | biostudies-arrayexpress
TranscriptomicsGlobal profiling of platinum drugs resistant genes in A549 cell lines
Non Small Cell Lung Cancer (NSCLC) causes the premature death of over 1 million people worldwide each year, but remains inadequately understood at the molecular level. To provide new insights for NSCLC treatment we performed a molecular characterisation of wild type and platinum drugs resistance in ...
ORGANISM(S): Homo sapiens 
2012-02-24 | E-MEXP-3123 | biostudies-arrayexpress
TranscriptomicsDistinct genetic alterations occur in ovarian tumor cells selected for combined resistance to carboplatin and docetaxel
Background: Current protocols for the treatment of ovarian cancer include combination chemotherapy with a platinating agent and a taxane. However, many patients experience relapse of their cancer and the development of drug resistance is not uncommon, making successful second line therapy difficult ...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-39337 | biostudies-arrayexpress
TranscriptomicsRedefining the Relevance of Established Cancer Cell Lines to the Study of Clinical Anti-Cancer Drug Resistance
Although in vitro models have been a cornerstone of anti-cancer drug development, their direct applicability to clinical cancer research has actually been uncertain. Using a state-of-the-art Taqman-based qRT-PCR assay, we investigated the multidrug resistance (MDR) transcriptome of six cancer types,...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-30034 | biostudies-arrayexpress
TranscriptomicsExpression and metylation data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines
This SuperSeries is composed of the following subset Series: GSE15372: Expression data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines. GSE15373: Promoter CpG island methylation data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines...
ORGANISM(S): Homo sapiens 
2009-04-17 | E-GEOD-15709 | biostudies-arrayexpress
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