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Plexin-B2 regulates mechanotension during multicellular organization
Plexin-B2 reduces glioma cell cohesion and regulates glioma-vascular interactions
To identify Plexin-B2-associated proteins, articular chondrocytes were untreated or treated with Sema4D. Plexin-B2-bound proteins were purified by immunoprecipitation using an anti-Plexin-B2 antibody, followed by mass spectrometry.
ORGANISM(S): Mus Musculus (mouse) 
During multicellular organization, individual cells need to constantly adjust intracellular contractility and junctional adhesive properties in order to maintain tissue cohesion and mechanotension. The membrane receptors linking external biochemical cues and internal cell mechanics are incompletely ...
ORGANISM(S): Homo sapiens 
2021-09-07 | GSE158017 | GEO
The diffuse invasion of glioblastoma (GBM) cells into healthy brain tissue is a main contributor for the high lethality of this most frequent form of malignant brain tumor. Plexins are cell surface receptors for semaphorins and control cell adhesion and cytoskeletal dynamics in development and in ad...
ORGANISM(S): Homo sapiens 
2021-01-13 | GSE126658 | GEO
Microglia and macrophages promote corralling, wound compaction and recovery in spinal cord injury via Plexin-B2
Tissue repair after spinal cord injury (SCI) requires mobilization of immune and glial cells to form a protective barrier that seals the wound and facilitates debris clearing, inflammatory containment, and matrix compaction. This process involves corralling, wherein phagocytic immune cells become co...
ORGANISM(S): Mus musculus 
2019-12-23 | GSE113566 | GEO
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