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UnknownPlGF knockout delays brain vessel growth and maturation upon systemic hypoxic challenge.
Not available
S-EPMC3318143 | biostudies-literature
TranscriptomicsPlacental growth factor as potential target against hepatocellular carcinoma in an orthotopic mouse model.
The placental growth factor (PlGF) is member of the vascular endothelial growth factor (VEGF)-family known to stimulate endothelial cell growth, migration and survival, attract angiocompetent macrophages and bone marrow progenitor cells and determine the metastatic niche. Unlike VEGF, genetic studie...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-35289 | biostudies-arrayexpress
UnknownDeletion of placental growth factor prevents diabetic retinopathy and is associated with Akt activation and HIF1α-VEGF pathway inhibition.
Not available
S-EPMC4274802 | biostudies-literature
UnknownPlacental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome.
Not available
S-EPMC11840504 | biostudies-literature
TranscriptomicsTranscriptomic data of liver endothelial cells from Alk1-(alias Acvrl1) knockout mice II
Hereditary hemorrhagic telangiectasia (HHT, alias Rendu-Osler-Weber syndrome) is an autosomal dominant genetic disease that causes vascular malformations in multiple organs. Malformations and shunts in the liver are relevant for the long-term prognosis as they can lead to heart failure. Moreover, th...
ORGANISM(S): Mus musculus 
2023-04-06 | GSE184747 | GEO
TranscriptomicsTranscriptomic data of whole liver from Alk1-(alias Acvrl1) knockout mice I
Hereditary hemorrhagic telangiectasia (HHT, alias Rendu-Osler-Weber syndrome) is an autosomal dominant genetic disease that causes vascular malformations in multiple organs. Malformations and shunts in the liver are relevant for the long-term prognosis as they can lead to heart failure. Moreover, th...
ORGANISM(S): Mus musculus 
2023-04-06 | GSE184746 | GEO
UnknownPlGF/FLT-1 deficiency leads to reduced STAT3-C/EBPβ signaling and aberrant polarization in decidual macrophages during early spontaneous abortion.
Not available
S-EPMC10074254 | biostudies-literature
UnknownNO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth.
Not available
S-EPMC3613910 | biostudies-literature
ProteomicsProteomics reveals ablation of PlGF down-regulate the insulin resistance pathway, increase antioxidant and neuroprotective proteins in the diabetic mice retina
PGF (Placental growth factor) is a member of the vascular endothelial growth factor (VEGF) sub-family a crucial factor in angiogenesis and vasculogenesis. Mechanisms by which PlGF expression is regulated remain to be investigated in diabetic retinopathy DR. However, the underlying molecular mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-13 | PXD010757 | Pride
Akita mice Proteomics Mass spectrometry Diabetes Plgf-knockout 
UnknownAdenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection.
Not available
S-EPMC3104770 | biostudies-literature
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