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TranscriptomicsOver expression of mRNA for multiple genes including insulin in the PLN of NOD is associated with Islet Autoimmunity
The aim of this study is to identify genes implicated in the early steps of the autoimmune process, prior to inflammation in type 1 diabetes. Early Insulin AutoAntibodies (E-IAA) have been used as subphenotypic marker to select individual animals as type 1 diabetes prone and to compare gene expressi...
ORGANISM(S): Mus musculus 
2009-10-02 | E-GEOD-15582 | biostudies-arrayexpress
UnknownIn PLN-R14del mice, SR structure restoration, rather than calcium cycling, is the dominant effector of PLN-ASO treatment.
Not available
S-EPMC12560789 | biostudies-literature
TranscriptomicsCorrection of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy [RNA-Seq]
Phospholamban R14del mutazion (PLN-R14del) has been identified in a large family pedigree in which heterozygous carriers exhibited inherited dilated cardiomyopathy (DCM) and death by middle age. To better understand the causal link between the mutations in PLN and DCM pathology, we derived induced p...
ORGANISM(S): Homo sapiens 
2015-02-09 | E-GEOD-65761 | biostudies-arrayexpress
UnknownLong-term reliability of the phospholamban (PLN) p.(Arg14del) risk model in predicting major ventricular arrhythmia: a landmark study.
Not available
S-EPMC10983074 | biostudies-literature
UnknownDeep neural network-based clustering of deformation curves reveals novel disease features in PLN pathogenic variant carriers.
Not available
S-EPMC10673970 | biostudies-literature
Genomics48hr 2a3 vs YTS177 CD4+ PLN T cell Microarray
48hr 2a3 vs YTS177 CD4+ PLN T cell Microarray
PRJNA744474 | ENA
TranscriptomicsTransgenic mice carrying the human PLN gene
These mice have been genetically modified so that the mouse PLN gene has been replace with the human PLN gene. Phopspholamban (PLN), the reversible inhibitor of the sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a), is a key regulator of myocyte Ca2+-cycling with a significant role in heart failure....
ORGANISM(S): Mus musculus 
2011-12-15 | GSE20172 | GEO
ProteomicsGene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modeling a European cardiomyopathy with global impact
Aims: A mutation in the phospholamban (PLN) gene, leading to deletion of Arg14 (R14del), has been associated with malignant arrhythmias and ventricular dilation. Identifying pre-symptomatic carriers with vulnerable myocardium is crucial because arrhythmia can result in sudden cardiac death, especial...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD031612 | Pride
Phospholamban Mouse model Tmt R14del Cardiomyopathy Lc-ms/ms 
TranscriptomicsTransgenic mice carrying the human PLN gene
These mice have been genetically modified so that the mouse PLN gene has been replace with the human PLN gene. Phopspholamban (PLN), the reversible inhibitor of the sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a), is a key regulator of myocyte Ca2+-cycling with a significant role in heart failure....
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-20172 | biostudies-arrayexpress
UnknownA study in Polish patients with cardiomyopathy emphasizes pathogenicity of phospholamban (PLN) mutations at amino acid position 9 and low penetrance of heterozygous null PLN mutations.
Not available
S-EPMC4421997 | biostudies-literature
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