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Metabolomics1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis
The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specificat...
2023-05-24 | MTBLS4854 | MetaboLights
MetabolomicsMetabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and recent studies have enabled generation of virtually pure hPSC-CMs with high efficiency in chemically defined and xeno-free conditions. Despi...
2018-04-24 | MTBLS425 | MetaboLights
MetabolomicsMetabolomic analysis of mouse embryonic fibroblasts, embryonic stem cells, and induced pluripotent stem cells
Not available
ORGANISM(S): Mus musculus 
ST000003 | MetabolomicsWorkbench
MetabolomicsStirred suspension bioreactors maintain naïve pluripotency of human pluripotent stem cells (hPSCs)
Not available
ORGANISM(S): Homo sapiens 
ST001377 | MetabolomicsWorkbench
MetabolomicsMetabolomic Profiling of Human Pluripotent Stem Cell Differentiation into Lung Progenitors
Not available
ORGANISM(S): Homo sapiens 
ST002055 | MetabolomicsWorkbench
ProteomicsEndogenous THBS1 is C-mannosylated by human induced pluripotent stem cells.
We used a human thrombospondin-1 (THBS1) fragment comprising thrombospondin type 1 repeats (TSRs) 1 to 3, which was recombinantly expressed in HEK 293T cells and digested with AspN to determine chromatographic retention times and to optimise MS parameters. We detected two peptides from TSR2 and TSR3...
ORGANISM(S): Homo Sapiens 
2021-05-12 | PXD024117 | panorama
MetabolomicsThe functional role of OGDH for maintaining mitochondrial respiration and identity of primed human embryonic stem cells

Human embryonic stem cells (hESCs) can self-renew infinitely or differentiate into the 3 germ layer lineages in vitro with certain cues, holding great promise to model early human embryo development ex vivo. It is wildly accepted that hESCs take advantage of both glycolysis and ...

2022-03-03 | MTBLS4223 | MetaboLights
ProteomicsProteome analysis of brainstem organoids from human pluripotent stem cells
Brain organoids derived from human pluripotent stem cells recapitulate the course of human brain development. We applied proteomic analysis to human brainstem organoids which were developed by a novel method.
ORGANISM(S): Homo Sapiens (human) 
2020-05-01 | PXD016807 | JPOST Repository
TranscriptomicsHuman oocytes reprogram adult somatic cells to pluripotent stem cells [Illumina]
The stem cell lines were generated according to the principle described in Noggle et al., Nature 2011, Oct 5;478(7367):70-5. doi: 10.1038/nature10397. Title: Human oocytes reprogram somatic cells to a pluripotent state. Abstract: The exchange of the oocyte's genome with the genome of a somatic cel...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-60360 | biostudies-arrayexpress
TranscriptomicsExpression data from human pluripotent stem cells and differentiated cells treated with pluripotent-specific inhibitors
The use of human pluripotent stem cells (hPSCs) in cell therapy is hindered by the tumorigenic risk from residual undifferentiated cells. Here we performed a high-throughput screen of over 52,000 small molecules, and identified 15 highly selective cytotoxic inhibitors of hPSCs (PluriSIns). Cellular ...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-37040 | biostudies-arrayexpress
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