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TranscriptomicsTranscription profiling of human heat shocked HeLa cell line with siRNA knockdown of HSF1
Although HSF1 is known to play an important role in regulating the cellular response to proteotoxic stressors, little is known about the structure and function of the HSF1 signaling network under both stressed and unstressed conditions. In this study, we used a combination of chromatin immunoprecip...
ORGANISM(S): Homo sapiens 
2007-06-22 | E-GEOD-3697 | biostudies-arrayexpress
TranscriptomicsMYC is an early response regulator of human adipogenesis in adipose stem cells
MYC is induced early in human adipose stem cells in response to a standard MDIR adipogenic cocktail. The objective of this experiment was to identify key gene networks impacted by MYC loss-of-function in a mixed donor pool of human derived adipose stem cells. Microarray analysis was used to identify...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-57538 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat female mouse lung tumors in rodent cancer bioassays - a 13 chemical training set
The primary goal of toxicology and safety testing is to identify agents that have the potential to cause adverse effects in humans. Unfortunately, many of these tests have not changed significantly in the past 30 years and most are inefficient, costly, and rely heavily on the use of animals. The r...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6116 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver treated with carcinogens and controls to identify biomarkers
Two-year rodent bioassays play a central role in evaluating both the carcinogenic potential of a chemical and generating quantitative information on the dose-response behavior for chemical risk assessments. The bioassays involved are expensive and time-consuming, requiring nearly lifetime exposures ...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-5128 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung treated with carcinogens and controls to evaluate carcinogenicity and identify biomarkers
Two-year rodent bioassays play a central role in evaluating both the carcinogenic potential of a chemical and generating quantitative information on the dose-response behavior for chemical risk assessments. The bioassays involved are expensive and time-consuming, requiring nearly lifetime exposures ...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-5127 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung fibroblasts exposed to vanadium pentoxide to identifiy genes associated with vanadium pentoxide-induced bronchitis
Exposure to vanadium pentoxide (V2O5) is a cause of occupational bronchitis. We evaluated gene expression profiles in cultured human lung fibroblasts exposed to V2O5 in vitro in order to identify candidate genes that could play a role in airway remodeling associated with V2O5-induced bronchitis. Gen...
ORGANISM(S): Homo sapiens 
2008-11-22 | E-GEOD-5339 | biostudies-arrayexpress
TranscriptomicsEffect of MWCNT on Lung Fibroblast gene expression
Multi-walled carbon nanotubes (MWCNT) cause lung fibrosis in rodents and exacerbate airway fibrosis in the mouse ovalbumin model of allergic asthma. Interleukin 13 (IL-13) is a key cytokine secreted by T helper type 2 (Th2) cells. IL-13 is up-regulated in human asthma and animal models that activat...
ORGANISM(S): Homo sapiens 
2013-05-29 | E-GEOD-43515 | biostudies-arrayexpress
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