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ProteomicsExtracellular vesicles from therapeutic grade allogeneic human placental stromal cells induce angiogenesis and modulate immunity
Allogeneic regenerative cell therapy has shown surprising results despite lack of engraftment of the transplanted cells. Their efficacy was so far considered to be mostly due to secreted trophic factors. We hypothesized that extracellular vesicles (EVs) can also contribute to their mode of action. H...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD014572 | Pride
Plx stromal cells Ev Cell therapy Tff Trps Pad Cli 
UnknownPosttransplant Intramuscular Injection of PLX-R18 Mesenchymal-Like Adherent Stromal Cells Improves Human Hematopoietic Engraftment in A Murine Transplant Model.
Not available
S-EPMC5827167 | biostudies-literature
UnknownPre-Administration of PLX-R18 Cells Protects Mice from Radiation-Induced Hematopoietic Failure and Lethality.
Not available
S-EPMC9601513 | biostudies-literature
UnknownMesenchymal Stromal Cells from Fetal and Maternal Placenta Possess Key Similarities and Differences: Potential Implications for Their Applications in Regenerative Medicine.
Not available
S-EPMC7017205 | biostudies-literature
TranscriptomicsMolecular changes induced in melanoma cells by stromal cells and anti-BRAF therapy.
Tumor-associated stromal cells can enable cancer cells to become insensitive to therapy. They can promote aggressive phenotype in cancer cells, which become less responsive to drugs such as BRAF inhibitors (BRAFi) used to treat melanomas. To clarify potential mechanism behind stromal influence on me...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-67637 | biostudies-arrayexpress
UnknownPlacenta-Expanded Stromal Cell Therapy in a Rodent Model of Simulated Weightlessness.
Not available
S-EPMC8073415 | biostudies-literature
UnknownPlacenta-Derived Mesenchymal Stromal-Like Cells Promote 3D-Engineered Muscle Tissue Differentiation and Vessel Network Maturation.
Not available
S-EPMC11935177 | biostudies-literature
TranscriptomicsA single intraarticular injection of placental‐expanded, mesenchymal-like stromal cells halts progression of experimental primary osteoarthritis through a combined modulation of inflammation and cartilage homeostasis
Background: Osteoarthritis (OA) is a highly prevalent degenerative joint disease, yet no effective disease-modifying treatments for OA are clinically available. The anti-inflammatory, immunomodulatory, and tissue regenerative properties of placenta-expanded mesenchymal-like adherent stromal cells (P...
ORGANISM(S): Cavia porcellus 
2025-12-31 | GSE305363 | GEO
UnknownHigher Loading of Gold Nanoparticles in PAD Mesenchymal-like Stromal Cells Leads to a Decreased Exocytosis.
Not available
S-EPMC9367297 | biostudies-literature
UnknownHIPGEN: a randomized, multicentre phase III study using intramuscular PLacenta-eXpanded stromal cells therapy for recovery following hip fracture arthroplasty : a study design.
Not available
S-EPMC9044085 | biostudies-literature
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