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TranscriptomicsFrequent occurrence of deletions in primary mediastinal B-cell lymphoma
Primary mediastinal B-cell lymphoma (PMBCL) is a distinct subtype of diffuse large B-cell lymphoma. PMBCL has been previously studied with a variety of genomic techniques resulting in frequent detection of chromosomal gains; however, chromosomal losses have been rarely reported. This finding contr...
ORGANISM(S): Homo sapiens 
2007-08-15 | E-GEOD-7383 | biostudies-arrayexpress
GenomicsAffymetrix SNP6 array data for NLPHL- and PMBCL-derived cell lines
We previously identified rearrangements involving CIITA, the master transcriptional regulator of MHC class II expression, as common mutational events in PMBCL and cHL. In order to inform on the prevalence and different types of structural genomic aberrations affecting CIITA in PMBCL and HL we perfor...
ORGANISM(S): Homo sapiens 
2015-10-12 | GSE73558 | GEO
GenomicsPMBCL IL4R DASL
Expression data for 42 PMBCL patient samples (32 IL4R WT cases and 10 cases with mutations in IL4R)
EGAD00010001542 | EGA
GenomicsHomo sapiens
Affymetrix SNP6 array data for NLPHL- and PMBCL-derived cell lines
PRJNA297332 | ENA
UnknownDLBCL with amplification of JAK2/PD-L2 exhibits PMBCL-like CNA pattern and worse clinical outcome resembling those with MYD88 L265P mutation.
Not available
S-EPMC7450805 | biostudies-literature
ProteomicsFrequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma (Phospho-Proteome)
Recent exome-wide studies discovered frequent somatic mutations in the epigenetic modifier ZNF217 in primary mediastinal B cell lymphoma (PMBCL) and related disorders. As functional consequences of ZNF217 alterations remain unknown, we comprehensively evaluated their impact in PMBCL. Targeted sequen...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD040928 | Pride
Znf217 Phosphoproteome Pmbcl Non-hodgkin lymphoma Genetics Mutation 
ProteomicsFrequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma (Global Proteome and PPI)
Recent exome-wide studies discovered frequent somatic mutations in the epigenetic modifier ZNF217 in primary mediastinal B cell lymphoma (PMBCL) and related disorders. As functional consequences of ZNF217 alterations remain unknown, we comprehensively evaluated their impact in PMBCL. Targeted sequen...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD034337 | Pride
Znf217 Pmbcl Non-hodgkin lymphoma Genetics Precision medicine Mutation Copy-number aberration 
GenomicsWhole exome sequencing of PMBCL
Whole exome sequencing of 8 PMBCL samples and paired normal samples and 14 unpaired PMCL samples.
EGAS00001006235 | EGA
GenomicsFrequent occurrence of deletions in primary mediastinal B-cell lymphoma
Primary mediastinal B-cell lymphoma (PMBCL) is a distinct subtype of diffuse large B-cell lymphoma. PMBCL has been previously studied with a variety of genomic techniques resulting in frequent detection of chromosomal gains; however, chromosomal losses have been rarely reported. This finding contras...
ORGANISM(S): Homo sapiens 
2007-08-15 | GSE7383 | GEO
GenomicsSomatic IRF4 mutations drive disease-defining expression signatures and thymic tropism in primary mediastinal large B-cell lymphoma [ATAC-seq]
Disease-defining signatures in lymphomas, driven by intricate molecular mechanisms, have advanced molecular taxonomies, refined classification, and may guide clinical management; however, the role of these signatures in driving disease hallmarks including subtype-specific organotropism remains large...
ORGANISM(S): Homo sapiens 
2025-07-25 | GSE294947 | GEO
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