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ProteomicsBacterial pore-forming toxin pneumolysin drives pathogenicity through host extracellular vesicles released during infection
In this study, we characterized the proteomic composition of extracellular vesicles released from human THP-1 monocytes challenged with the pneumococcal pore-forming toxin, pneumolysin. We found that the vesicles shed from pneumolysin challenged cells are selectively enriched in key inflammatory hos...
ORGANISM(S): Homo sapiens (Human) 
2024-07-31 | PXD052436 | Pride
Human Monocytes Pneumolysin challenge Inflammation Streptococcus pneumoniae Lc-ms Exosome cargo 
TranscriptomicsTranscriptional response of monocyte-derived macrophages to stimulation with wildtype or pneumolysin-deficient Streptrococcus pneumoniae in the presence or absence of cytochalasin D
We used genome-wide transcriptional profiling by microarray to assess the contribution of pneumolysin on macrophage innate immune responses to the TIGR4 strain of Streptococcus pneumoniae (Spn). We focused on the early transcriptional responses at 4 hours after inoculation of human blood monocyte-de...
ORGANISM(S): Homo sapiens 
2021-03-31 | E-MTAB-8947 | biostudies-arrayexpress
GenomicsImpact of Endogenous Pneumococcal Hydrogen Peroxide on the activity and release of Pneumolysin
Impact of Endogenous Pneumococcal Hydrogen Peroxide on the activity and release of Pneumolysin
PRJNA1003806 | ENA
GenomicsMucin O-glycans protect host cells by tempering pneumolysin expression in Streptococcus pneumoniae
Mucin O-glycans protect host cells by tempering pneumolysin expression in Streptococcus pneumoniae
PRJNA1105090 | ENA
TranscriptomicsImpact of Endogenous Pneumococcal Hydrogen Peroxide on the activity and release of Pneumolysin
Streptococcus pneumoniae is the leading cause of community-acquired pneumonia. The release of the pore-forming cholesterol-dependent cytolysin (CDC) pneumolysin (PLY) and hydrogen peroxide (H2O2), a physiological metabolite, is an important virulence determinant of pneumococci.
ORGANISM(S): Streptococcus pneumoniae 
2023-08-09 | GSE240442 | GEO
UnknownIncomplete pneumolysin oligomers form membrane pores.
Not available
S-EPMC4043118 | biostudies-literature
UnknownPolyvalent Immunoglobulin Preparations Inhibit Pneumolysin-Induced Platelet Destruction.
Not available
S-EPMC9385248 | biostudies-literature
UnknownIdentification of invasive serotype 1 pneumococcal isolates that express nonhemolytic pneumolysin.
Not available
S-EPMC1351962 | biostudies-literature
Unknownβ-sitosterol interacts with pneumolysin to prevent Streptococcus pneumoniae infection.
Not available
S-EPMC4668377 | biostudies-literature
TranscriptomicsInfection with Streptococcus pneumoniae triggers progression of pulmonary fibrosis by pneumolysin
A two-hit model of adenoviral vector delivery of active transforming growth factor-β (TGFb) 1 to induce fibrosis in mice in conjunction with treatment of the mice with purified pneumolysin from Streptococcus pneumoniae was applied to characterize the role of this virulence factor on fibrosis perpetu...
ORGANISM(S): Mus musculus 
2017-09-01 | GSE52890 | GEO
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