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ProteomicsBacterial pore-forming toxin pneumolysin drives pathogenicity through host extracellular vesicles released during infection
In this study, we characterized the proteomic composition of extracellular vesicles released from human THP-1 monocytes challenged with the pneumococcal pore-forming toxin, pneumolysin. We found that the vesicles shed from pneumolysin challenged cells are selectively enriched in key inflammatory hos...
ORGANISM(S): Homo sapiens (Human) 
2024-07-31 | PXD052436 | Pride
Human Monocytes Pneumolysin challenge Inflammation Streptococcus pneumoniae Lc-ms Exosome cargo 
TranscriptomicsAffymetrix microarray of human monocyte derived macrophages following challenge with Streptococcus pneumoniae with or without pneumolysin
Transcriptional profiling of primary monocyte derived macrophages (MDMs) comparing control untreated MDMs with MDMs exposed with Serotype 2 Streptococcus pneumoniae (D39) strain (MOI 10) for 3 hours) Three-condition experiment, control MDMs vs. D39 infected MDMs vs Stop infected MDMs. Biological re...
ORGANISM(S): Homo sapiens 
2021-03-01 | E-MTAB-9055 | biostudies-arrayexpress
TranscriptomicsStreptococcus pneumoniae in a biofilm are hyper-adhesive, avirulent, and when used as a killed whole-cell vaccine confers protection against lethal challenge
For Streptococcus pneumoniae, biofilms have been suggested to promote long-term colonization of the nasopharynx and contribute to the pathology of recurrent middle ear infections. To date numerous studies have investigated the contribution of specific genetic determinants for the development of pneu...
ORGANISM(S): Streptococcus pneumoniae 
2013-04-01 | E-GEOD-26976 | biostudies-arrayexpress
UnknownPneumolysin Is Responsible for Differential Gene Expression and Modifications in the Epigenetic Landscape of Primary Monocyte Derived Macrophages.
Not available
S-EPMC8145618 | biostudies-literature
UnknownPneumolysin and the bacterial capsule of Streptococcus pneumoniae cooperatively inhibit taxis and motility of microglia.
Not available
S-EPMC6525981 | biostudies-literature
UnknownPreclinical in vitro and in vivo profile of a highly-attenuated, broadly efficacious pneumolysin genetic toxoid.
Not available
S-EPMC8237519 | biostudies-literature
UnknownA fusion protein comprising pneumococcal surface protein A and a pneumolysin derivate confers protection in a murine model of pneumococcal pneumonia.
Not available
S-EPMC9728834 | biostudies-literature
UnknownRole of astroglial Connexin 43 in pneumolysin cytotoxicity and during pneumococcal meningitis.
Not available
S-EPMC7793270 | biostudies-literature
UnknownPneumolysin with low hemolytic activity confers an early growth advantage to Streptococcus pneumoniae in the blood.
Not available
S-EPMC3187248 | biostudies-literature
UnknownAdditive attenuation of virulence of Streptococcus pneumoniae by mutation of the genes encoding pneumolysin and other putative pneumococcal virulence proteins.
Not available
S-EPMC97112 | biostudies-literature
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