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ProteomicsCharacterization of the pocket mutant of cyclin B1
The APC complex was purified from insect cells and an in vitro phosphorylation purified WT cyclin B1 or pocket mutant cyclin B1 was performed. Phosphorylation sites were detected by mass spectrometry (in vitro data). WT cyclin B1 and mutant cyclin B1 was transfected in cells and the APC complex imm...
ORGANISM(S): Homo sapiens (Human) 
2025-04-03 | PXD047204 | Pride
Phosphorylation Cyclin b1 Pocket mutant cyclin b1 Immunoprecipitation Apc complex 
ProteomicsPositively charged specificity site in cyclin B1 is essential for mitotic fidelity
Phosphorylation of substrates by cyclin-dependent kinases (CDKs) is the driving force of cell cycle progression. Several CDK-activating cyclins are involved, yet how they contribute to substrate specificity is still poorly understood. Here, we discovered that a positively charged pocket in cyclin B1...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048838 | Pride
Cyclin b Phosphate-binding pocket Mitosis Spindle Cdk1 Apc/c Ube2s 
UnknownPositively charged specificity site in cyclin B1 is essential for mitotic fidelity.
Not available
S-EPMC11747444 | biostudies-literature
UnknownLIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression.
Not available
S-EPMC3903767 | biostudies-literature
TranscriptomicsRegulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription
Tissue-specific transcriptional activity is silenced in mitotic cells but it remains unclear whether the mitotic regulatory machinery interacts with tissue-specific transcriptional programs. We show that such cross-talk involves the controlled interaction between core subunits of the anaphase-promot...
ORGANISM(S): Homo sapiens 
2022-03-11 | GSE181639 | GEO
UnknownRegulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription.
Not available
S-EPMC9018835 | biostudies-literature
TranscriptomicsExpression data from hESCs expressing RB7LP or T121
We used microarray analysis to study the expression differences between controls and hESCs expressing RB7LP for 3 days, and controls and hESCs expressing T121 for 3 days. RB7LP is the large pocket fragment of the retinoblastoma protein (RB) fused to GFP, in which seven phosphorylation sites for Cdk ...
ORGANISM(S): Homo sapiens 
2012-06-28 | E-GEOD-29783 | biostudies-arrayexpress
GenomicsRegulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription
Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription
PRJNA752785 | ENA
TranscriptomicsOpioid exacerbates gut dysbiosis in a murine model Citrobacter rodentium infection
Opioids analgesics are frequently prescribed in the United States and worldwide. However, serious side effects such as addiction, immunosuppression and gastrointestinal symptoms limit their use. It has been recently demonstrated that morphine treatment results in significant disruption in gut barrie...
ORGANISM(S): Mus musculus 
2020-02-18 | E-MTAB-7503 | biostudies-arrayexpress
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