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TranscriptomicsRNA-Seq of six mammals
Homologous vertebrate tissues express a highly conserved set of transcribed genes; paradoxically, expression of tRNAs that are required to translate mRNAs into proteins have been reported to be divergent. To resolve this paradox, we mapped the genome-wide occupancy of pol III in primary tissues iso...
ORGANISM(S): Mus musculus 
2011-07-29 | E-MTAB-424 | biostudies-arrayexpress
ProteomicsA Breast Cancer Stem Cell Niche Supported by Juxtacrine Signaling from Monocytes and Macrophages
Lu H, Clauser KR, Tam WL, Fröse J, Ye X, Eaton EN, Reinhart F, Donnenberg VS, Bhargava R, Carr SA, Weinberg RA, Nature Cell Biol 2014 in press
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-08-04 | MSV000078799 | MassIVE
TranscriptomicsEffects of Rituximab on global gene expression profiles in the RA synovium
Objective: Rituximab displays therapeutic benefits in the treatment of rheumatoid arthritis (RA) patients resistant to TNF blockade. However, the precise role of B cells in the pathogenesis of RA is still unknown. In this study we investigated the global molecular effects of rituximab in synovial bi...
ORGANISM(S): Homo sapiens 
2010-10-19 | E-GEOD-24742 | biostudies-arrayexpress
UnknownMitotic Transcriptional Activation: Clearance of Actively Engaged Pol II via Transcriptional Elongation Control in Mitosis.
Not available
S-EPMC5548174 | biostudies-literature
UnknownPAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II.
Not available
S-EPMC4679144 | biostudies-literature
TranscriptomicsReplication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast
Histone modifications affect DNA-templated processes ranging from transcription to genomic replication. In this study, we examine the cell cycle dynamics of the trimethylated form of histone H3 lysine 4 (H3K4me3), a mark of active chromatin that is viewed as “long-lived” [1], and that is involved in...
ORGANISM(S): Saccharomyces cerevisiae 
2009-01-28 | GSE14565 | GEO
TranscriptomicsInfluence of BrpA on critical virulence attributes of Streptococcus mutans
Streptococcus mutans, the primary etiological agent of human dental caries, has developed multiple mechanisms to colonize and form biofilms on the tooth surface. The brpA gene codes for a predicted surface-associated protein with apparent roles in biofilm formation, autolysis, and cell division. In ...
ORGANISM(S): Streptococcus mutans 
2008-08-30 | E-GEOD-11773 | biostudies-arrayexpress
TranscriptomicsReplication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast
Histone modifications affect DNA-templated processes ranging from transcription to genomic replication. In this study, we examine the cell cycle dynamics of the trimethylated form of histone H3 lysine 4 (H3K4me3), a mark of active chromatin that is viewed as â??long-livedâ?? [1], and that is involve...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-24 | E-GEOD-14565 | biostudies-arrayexpress
TranscriptomicsThe Role of CcpA in Gene Regulation in Streptococcus mutans
CcpA is a global regulator of transcription in Gram-positive bacteria that controls gene expression in response to carbohydrate availability. Using the fructan hydrolase (fruA) gene of S. mutans as a model, we demonstrate that CcpA does indeed play a major role in carbohydrate catabolite repression...
ORGANISM(S): Streptococcus mutans 
2008-05-01 | E-GEOD-8850 | biostudies-arrayexpress
TranscriptomicsRegulator trafficking on bacterial transcription units in vivo
The in vivo trafficking patterns on DNA by the bacterial regulators of transcript elongation Sigma70, Rho, NusA, and NusG and the explanation for high promoter-proximal levels or peaks of RNA polymerase (RNAP) are unknown. Genome-wide ChIP-chip on E. coli revealed distinct association patterns of r...
ORGANISM(S): Escherichia coli 
2010-05-14 | E-GEOD-13938 | biostudies-arrayexpress
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