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ProteomicstRNA 3' shortening by LCCR4 as a response to stress in Trypanosoma brucei
Sensing of environmental cues is crucial for cell survival. To adapt to changes in their surroundings cells need to tightly control the repertoire of genes expressed at any time. Regulation of translation is key, especially in organisms in which transcription is hardly controlled, like Trypanosoma b...
ORGANISM(S): Trypanosoma brucei 
2021-01-13 | PXD021533 | Pride
Stress Trna Ccr4 Brucei Translation 
ProteomicstRNA synthetases are recruited to yeast ribosomes by rRNA expansion segment 7L but do not require association for func-tionality
Ribosomes expanded during evolution on the protein and rRNA level. The expanded regions do not change the active sites of ribosomes and thus do not alter the peptide bond formation reaction catalysed by the ribosome. To what purpose these expansions were selected is not fully understood. Here, we de...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-16 | PXD029751 | Pride
Aminoacyl-trna synthetases Yeast Rrna expansion segments Ribosome biology Translation regulation 
ProteomicstRNA 3' shortening by LCCR4 as a response to stress in Trypanosoma brucei
Sensing of environmental cues is crucial for cell survival. To adapt to changes in their surroundings cells need to tightly control the repertoire of genes expressed at any time. Regulation of translation is key, especially in organisms in which transcription is hardly controlled, like Trypanosoma b...
ORGANISM(S): Trypanosoma brucei 
2021-01-13 | PXD021540 | Pride
Stress Trna Ccr4 Brucei Translation 
ProteomicsDynamic 23S rRNA modification ho5C2501 benefits Escherichia coli under oxidative stress
Post-transcriptional modifications are added to ribosomal RNAs (rRNAs) to govern ribosome biogenesis and to fine-tune protein biosynthesis. RlhA, a dedicated modification enzyme, adds a unique 5-hydroxycytidine (ho5C) at 23S rRNA position 2501 in E. coli and related bacteria. However, the molecular ...
ORGANISM(S): Escherichia coli 
2022-02-16 | PXD025875 | Pride
E. coli Ribosome Dps Oxidative stress Rlha Rna modifications 
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