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ProteomicsInterrogating the interaction of fission yeast RNA-binding protein Puf3 with the Ccr4-Not complex using crosslinking mass spectrometry
mRNA decay is a key determinant of gene regulation, initiated by the shortening of mRNA poly(A) tails by the CCR4-NOT deadenylation complex. Specificity is achieved through RNA adaptors—RNA-binding proteins that recruit CCR4-NOT to specific substrate mRNAs in a regulated manner. However, the molecul...
ORGANISM(S): Schizosaccharomyces pombe 927 
2025-09-03 | PXD055147 | Pride
Crosslinking ms Idr Protein-protein interaction Rna binding protein puf3 Ccr4-not complex 
ProteomicsIdentification of Plasmodium yoelii CCR4/CAF1/CAF1d Binding partners and total proteomics of Py17XNL by Immunoprecipitation/nano LC-MS/MS
The transmission of the malaria parasite between mosquitoes and mammals requires translational repression to ensure that only the proper proteins are expressed at the right time, while still allowing the parasite to prepare the mRNAs it will need for the next developmental stage. With relatively few...
ORGANISM(S): Plasmodium yoelii yoelii 17XNL 
2019-01-07 | PXD007042 | Pride
Ccr4 Plasmodium Py17xnl Caf1 
ProteomicsIdentification of acetylation-regulated interactors of the human CCR4-NOT complex
The evolutionarily conserved CCR4-NOT complex acts as a central player in the control of mRNA turnover and mediates accelerated mRNA degradation upon histone deacetylase (HDAC) inhibition. Here, we explored acetylation-induced changes in the composition of the CCR4-NOT complex by purification of the...
ORGANISM(S): Homo sapiens (Human) 
2021-12-15 | PXD027237 | Pride
Rnf219 Mrna turnover Protein acetylation Deadenylation E3 ubiquitin ligase Ccr4-not complex 
TranscriptomicsSpecific Roles for the Ccr4-Not Complex Subunits in Expression of the Genome
These Affymetrix data were used to determine the role of each non-essential subunit of the conserved Ccr4-Not complex in the control of gene expression in the yeast S. cerevisiae. The study was performed with cells growing exponentially in high glucose and with cells grown to glucose depletion. Spec...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-10 | E-GEOD-10521 | biostudies-arrayexpress
GenomicsExpression data from wild-type, ccr4∆, and ccr4∆ pbp1∆ yeast cells.
Expression data from wild-type, ccr4∆, and ccr4∆ pbp1∆ yeast cells.
PRJNA816723 | ENA
ProteomicsCcr4-Not ubiquitin ligase signaling regulates ribosomal protein homeostasis and inhibits 40S ribosomal autophagy
The Ccr4-Not complex containing the Not4 ubiquitin ligase regulates gene transcription and mRNA decay, yet it also has poorly defined roles in translation, proteostasis, and endolysosomal-dependent nutrient signaling. To define how Ccr4-Not mediated ubiquitin signaling regulates these additional pro...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-10-17 | PXD044420 | Pride
Autophagy Endolysomal Ribosome Ccr4-not Not4 
TranscriptomicsRNA-seq to identify the role of mRNA decay in mouse adipose tissues
The CCR4-NOT deadenylase complex has a critical function to trigger mRNA decay and various biological events. To understand roles of the complex in adipocyte function, we compare RNA expression between control and Cnot complex-deficient brown and white adipose tissues.
ORGANISM(S): Mus musculus 
2019-10-24 | E-MTAB-8366 | biostudies-arrayexpress
TranscriptomicsExamination of mRNA decay rate in mature adipocytes
The CCR4-NOT deadenylase complex has a critical function to trigger mRNA decay and various biological events. To understand roles of the complex in adipocyte function, we compare mRNA half-lives between control and Cnot complex-deficient mature adipocytes from iWAT and BAT.
ORGANISM(S): Mus musculus 
2019-10-24 | E-MTAB-8371 | biostudies-arrayexpress
TranscriptomicsExamination of mRNA decay rate in mouse embryonic fibroblasts
The CCR4-NOT dedadenylase complex is essential for mRNA decay and various biological events.To understand roles of the complex in mouse embryonic fibroblasts, we compared mRNA half-lives between control and Cnot complex-deficient mouse embryonic fibroblasts
ORGANISM(S): Mus musculus 
2020-01-29 | E-MTAB-8287 | biostudies-arrayexpress
TranscriptomicssiRNA profiling human adult T cell leukemia reveals Fra-2 promotes CCR4 expression and cell proliferation
The 4　Fra2-targeting siRNA and 4 control-siRNA samples were used for analysis. Experiment Overall Design: A microarray procedure was performed according to the Affymetrix protocols (Santa Clara, CA). In brief, total RNA extracted from the tumor samples was analyzed with the Agilent 2100 Bioanalyze...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6379 | biostudies-arrayexpress
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