Deadenylation - OmicsDI

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Rapid nuclear deadenylation of mammalian messenger RNA

PRJNA779378 | ENA

Transcription profiling of Zebrafish embryos investigating the effect of miR-430 microRNA on deadenylation and clearance of maternal mRNAs

MicroRNAs comprise 1-3% of all vertebrate genes, but their in vivo functions and mechanisms of action remain largely unknown. Zebrafish miR-430 is expressed at the onset of zygotic transcription and regulates morphogenesis during early development. Using a microarray approach and in vivo target vali...

ORGANISM(S): Danio rerio

2007-10-05 | E-GEOD-4201 | biostudies-arrayexpress

Cnot3-dependent mRNA deadenylation safeguards the pluripotent state

Poly(A)-tail length and mRNA deadenylation play important roles in post-transcriptional gene regulation. Here, we report the regulation of mRNA expression, half-life, and polysome association in mouse embryonic stem cells by the Cnot3 subunit in the Ccr4-Not mRNA deadenylase complex. To determine th...

ORGANISM(S): Mus musculus

2016-08-10 | E-GEOD-84953 | biostudies-arrayexpress

RNAi knock-down of CAF1-CCR4-NOT1 deadenylase complex or AGO1 in D. melanogaster S2 cells

miRNAs silence gene expression by repressing translation and/or by promoting mRNA decay. AGO1 is a key protein required for miRNA-mediated gene silencing. In animal cells, mRNA degradation of partially complementary miRNA targets occurs via deadenylation by the CAF1-CCR4-NOT1 deadenylase complex, fo...

ORGANISM(S): Drosophila melanogaster

2008-12-03 | E-MEXP-1713 | biostudies-arrayexpress

Rapid nuclear deadenylation of mammalian messenger RNA

Poly(A) tails protect RNAs from degradation and deadenylation rates determine RNA stability. Deadenylation has mostly been investigated within the cytoplasm and the dynamics of poly(A) tail length after transcription are not well understood. Combining long-read sequencing with metabolic labeling and...

ORGANISM(S): Mus musculus Homo sapiens

2023-01-07 | GSE188539 | GEO

mRNA deadenylation modeling at permissive and stress conditions reveals complex relations to decay

PRJEB75356 | ENA

Modeling of mRNA deadenylation rates reveal a complex relationship between mRNA deadenylation and decay.

Not available

S-EPMC11649921 | biostudies-literature

Decoupling of degradation from deadenylation reshapes poly(A) tail length in yeast meiosis

PRJNA719131 | ENA

mRNA deadenylation modeling at permissive and stress conditions reveals complex relations to decay

PRJNA1138735 | ENA

Nanopore RNA sequencing in S. cerevisiae strains defective for decapping and deadenylation