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TranscriptomicsRNAi knock-down of CAF1-CCR4-NOT1 deadenylase complex or AGO1 in D. melanogaster S2 cells
miRNAs silence gene expression by repressing translation and/or by promoting mRNA decay. AGO1 is a key protein required for miRNA-mediated gene silencing. In animal cells, mRNA degradation of partially complementary miRNA targets occurs via deadenylation by the CAF1-CCR4-NOT1 deadenylase complex, fo...
ORGANISM(S): Drosophila melanogaster 
2008-12-03 | E-MEXP-1713 | biostudies-arrayexpress
ProteomicsIdentification of Plasmodium yoelii CCR4/CAF1/CAF1d Binding partners and total proteomics of Py17XNL by Immunoprecipitation/nano LC-MS/MS
The transmission of the malaria parasite between mosquitoes and mammals requires translational repression to ensure that only the proper proteins are expressed at the right time, while still allowing the parasite to prepare the mRNAs it will need for the next developmental stage. With relatively few...
ORGANISM(S): Plasmodium yoelii yoelii 17XNL 
2019-01-07 | PXD007042 | Pride
Ccr4 Plasmodium Py17xnl Caf1 
GenomicsInteractions of CAF1-NOT complex components from Trypanosoma brucei
Our trypanosome yeast two-hybrid prey library was made by random shotgun genomic cloning. NOT2, NOT10, NOT11 and CAF40 were used as baits to screen the library by mating. Diploid progeny were subjected to selection, resulting in between 100 and 800 surviving colonies, from which inserts were amplifi...
ORGANISM(S): Trypanosoma brucei 
2022-01-14 | E-MTAB-4946 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of Zea mays chloroplast extracts prepared from wild type and CAF1-deficient tissue
Immunoprecipitation of the chloroplast splicing factor CAF1 and analysis of bound RNAs with a complete Zea mays cpDNA microarray.
ORGANISM(S): Zea mays 
2005-08-01 | E-MEXP-318 | biostudies-arrayexpress
ProteomicsThe chromatin assembly factor complex 1 (CAF1) and 5-Azacytidine (5-AzaC) affect cell motility in Src-transformed human epithelial cells
Tumor invasion into surrounding stromal tissue is a hallmark of high-grade, metastatic cancers. Oncogenic transformation of human epithelial cells in culture can be triggered by activation of v-Src kinase, resulting in increased cell motility, invasiveness and tumorigenicity and provides a valuable ...
ORGANISM(S): Homo sapiens (Human) 
2016-12-20 | PXD005494 | Pride
Epigenetics Proteomics Invasion 
GenomicsA Possible Role for CAF1 in the Incorporation of H3.3 in Arabidopsis [RNA-Seq]
A Possible Role for CAF1 in the Incorporation of H3.3 in Arabidopsis [RNA-Seq]
PRJNA1247479 | ENA
GenomicsA Role for CAF1 in the Incorporation of H3.3 in Arabidopsis [ChIP-seq]
A Role for CAF1 in the Incorporation of H3.3 in Arabidopsis [ChIP-seq]
PRJNA1247475 | ENA
GenomicsA Role for CAF1 in the Incorporation of H3.3 in Arabidopsis [ChIP-seq]
Eukaryotic organisms organize their genetic material in chromatin rather than unprotected DNA. Efficient chromatin assembly is essential for all DNA-templated processes, including replication, transcription, and DNA repair. Our research focused on two major histone H3 deposition complexes: Chromatin...
ORGANISM(S): Arabidopsis thaliana 
2025-04-12 | GSE293945 | GEO
TranscriptomicsA Possible Role for CAF1 in the Incorporation of H3.3 in Arabidopsis [RNA-Seq]
Eukaryotic organisms organize their genetic material in chromatin rather than unprotected DNA. Efficient chromatin assembly is essential for all DNA-templated processes, including replication, transcription, and DNA repair. Our research focused on two major histone H3 deposition complexes: Chromatin...
ORGANISM(S): Arabidopsis thaliana 
2025-04-12 | GSE293944 | GEO
TranscriptomicsThe roles of 3’-exoribonucleases and the exosome in trypanosome mRNA degradation
The roles of 3’-exoribonucleases and the exosome in trypanosome mRNA degradation; 30 min after actinomycin D +sinefungin, RNAi against CAf1, CNOT10, PAN2. These are really old data that hadn't been deposited.The datasets called RNA1, RNA2, RNA3 and RNA4 are almost certainly, from their location in t...
ORGANISM(S): Trypanosoma brucei brucei 
2021-03-11 | E-MTAB-10260 | biostudies-arrayexpress
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