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TranscriptomicsPhenotype and expression profile of S. erythraea rifampicin-resistant (rif) mutants affected in erythromycin production
In this study we have used the rifampicin selection as a tool to genetically improve the erythromycin producer Saccharopolyspora erythraea. Two rifampicin-resistant (rif) mutants, rif1 and rif6, have been characterized in more detail. With respect to the parental strain NRRL2338, rif1 (harboring the...
ORGANISM(S): Saccharopolyspora erythraea 
2009-04-12 | E-GEOD-12017 | biostudies-arrayexpress
ProteomicsThe S. cerevisiae SUMO stress response is a transcription-dependent conjugation-deconjugation cycle
Not available
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2014-06-16 | MSV000078739 | MassIVE
TranscriptomicsExpression data from Saccharomyces cerevisiae strains carrying the rna14-1 or the rna15-1 allele
In the yeast Saccharomyces cerevisiae, cleavage factor I (CFI) and cleavage and polyadenylation factor (CPF) build the core of the transcription termination machinery. CFI comprises the Rna14, Rna15, Pcf11, and Clp1 proteins, as well as the associated Hrp5 RNA-binding protein. We found that CFI part...
ORGANISM(S): Saccharomyces cerevisiae 
2014-03-31 | E-GEOD-50947 | biostudies-arrayexpress
GenomicsHog1 controls global reallocation of RNA Pol II upon osmotic shock
When challenged with osmotic shock, S. cerevisiae induces hundreds of genes, despite a global reduction in transcriptional capacity. The mechanisms that regulate this rapid reallocation of transcriptional resources are not known. Here we show that redistribution of RNA Pol II upon stress requires ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-07-15 | E-GEOD-38208 | biostudies-arrayexpress
GenomicsTCERG1 regulates alternative splicing of Bcl-x gene by modulating the rate of RNAPII transcription
Complex functional coupling exists between transcriptional elongation and pre-mRNA alternative splicing. Pausing sites and changes in the rate of transcription by RNAPII may therefore have a fundamental impact in the regulation of alternative splicing. Here, we show that the elongation and splicing-...
ORGANISM(S): Homo sapiens 
2012-01-12 | E-GEOD-33716 | biostudies-arrayexpress
TranscriptomicsExpression of subtelomeric lncRNAs links telomeres maintenance with RNA decay in S. cerevisiae
Long non-coding RNAs (lncRNAs) have been shown to regulate gene expression, chromatin domains and chromosome stability in eukaryotic cells. Recent observations have reported the existence of telomere associated long ncRNAs (TERRA, telomeric repeat containing RNA) in mammalian and yeast cells but the...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-30 | E-GEOD-67585 | biostudies-arrayexpress
UnknownThe Controversial Role of 24-S-Hydroxycholesterol in Alzheimer's Disease.
Not available
S-EPMC8151638 | biostudies-literature
GenomicsPol II chromatin immunoprecipitation in S. cerevisiae
In Saccharomyces cerevisiae short non-coding RNA (ncRNA) generated by RNA Polymerase II (Pol II) are terminated by the NRD complex consisting of Nrd1, Nab3 and Sen1. We now show that Pcf11, a component of the cleavage and polyadenylation complex (CPAC), is generally required for NRD-dependent transc...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-02 | E-GEOD-67483 | biostudies-arrayexpress
GenomicsGenome-wide distribution of AdpA, a global regulator for secondary metabolism and morphological differentiation in Streptomyces [solid]
AdpA is a global transcriptional activator triggering morphological differentiation and secondary metabolism in Streptomyces griseus. AdpA influences expression of >1,000 genes, but the overall picture of AdpA regulon has been obscure. Here, we took snapshots of distribution of AdpA across the chrom...
ORGANISM(S): Streptomyces griseus 
2012-04-03 | E-GEOD-34037 | biostudies-arrayexpress
TranscriptomicsCryptic Transcription in a set2∆ in Saccharomyces cerevisiae
In cells lacking the histone methyltransferase Set2, initiation of RNA polymerase II transcription occurs inappropriately within the protein-coding regions of genes, rather than being restricted to the proximal promoter. Here, we mapped the transcripts produced in an S. cerevisiae strain lacking Set...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-17 | E-GEOD-13310 | biostudies-arrayexpress
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