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TranscriptomicsEpigenetic regulation of cell type-specific expression patterns in the human mammary epithelium [SAGE-Seq]
Here we describe the application of high-throughput sequencing technology for profiling histone and DNA methylation, and gene expression patterns of normal human mammary progenitor-enriched and luminal lineage-committed cells. We observed significant differences in histone H3 lysine 27 tri-methylati...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-26140 | biostudies-arrayexpress
ProteomicsKDM4C histone demethylase connects chromatin remodeling and metabolism in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a highly aggressive disease with inferior prognosis necessitating the discovery of novel actionable targets. Here, we show that KDM4C, a histone demethylase amplified in a subset of TNBC, is a driver of TNBC tumor growth. Integrative multi-omic analysis demons...
ORGANISM(S): Homo sapiens (Human) 
2025-04-12 | PXD031768 | Pride
Kdm4c Triple negative breast cancer Histone tail clipping Cathepsin l Grhl2 
MetabolomicsGNPS - JAK-STAT signaling in inflammatory breast cancer enables chemotherapy-resistant cell states
Inflammatory breast cancer (IBC) is a difficult-to-treat disease with poor clinical outcomes due to high risk of metastasis and resistance to treatment. We previously described a CD44+CD24-pSTAT3+ cancer cell subpopulation with stem cell-like features in breast cancer that is dependent on JAK/STAT3 ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-04 | MSV000090647 | GNPS
TranscriptomicsResponse and resistance to BET bromodomain inhibitors in triple negative breast cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-01-07 | E-GEOD-63584 | biostudies-arrayexpress
TranscriptomicsNovel estrogen and tamoxifen induced genes
The breast cancer promoting effects of estrogen and the chemopreventive effects of tamoxifen are thought to be mediated by the estrogen receptor, a ligand-dependent transcription factor. Therefore, comprehensive analysis of gene expression profiles following estrogen or tamoxifen treatment may help ...
ORGANISM(S): Homo sapiens 
2003-07-16 | E-GEOD-507 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of breast cancer cell-lines
Recurrent mutations in histone modifying enzymes in multiple cancer types imply key roles in tumorigenesis. However, the functional relevance of these mutations remains unknown. Here we show that the JARID1B histone H3 lysine 4 demethylase is frequently amplified and overexpressed in luminal breast ...
ORGANISM(S): Homo sapiens 
2014-06-17 | E-GEOD-45732 | biostudies-arrayexpress
ProteomicsLoss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3
Histone lysine methyltransferases KMT2C and KMT2D are among the most commonly mutated genes in the highly metastatic TNBC subtype of breast cancer. However, it is not known if mutations of either of these genes similarly effect epigenomic and transcriptomic landscape or if a specific downstream targ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-07 | MSV000094701 | MassIVE
ProteomicsEpigenetic heterogeneity and transcriptional drivers of triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a heterogeneous disease with limited treatment options. To characterize TNBC heterogeneity, we defined transcriptional, epigenetic, and metabolic subtypes, and subtype-driving super-enhancers and transcription factors by combining functional and molecular prof...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-17 | MSV000091071 | MassIVE
GenomicsGenome-wide location analysis in breast cancer cell-lines
Recurrent mutations in histone modifying enzymes in multiple cancer types imply key roles in tumorigenesis. However, the functional relevance of these mutations remains unknown. Here we show that the JARID1B histone H3 lysine 4 demethylase is frequently amplified and overexpressed in luminal breast ...
ORGANISM(S): Homo sapiens 
2014-06-17 | E-GEOD-46055 | biostudies-arrayexpress
ProteomicsZBTB7A and KDM5 activity co-regulate NF-kB target gene expression and oxidative phosphorylation in triple negative breast cancer
We previously described that the KDM5B histone H3 lysine 4 (H3K4) demethylase is an oncogene in estrogen receptor-positive breast cancer. Here we report that KDM5A is amplified and overexpressed in basal breast tumors and is associated with chemotherapy resistance. Using CRISPR knockout viability sc...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-04-02 | MSV000094452 | MassIVE
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