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ProteomicsKDM4C epigenetically regulates and forms a feed-forward loop with ALDH1A3 to maintain gastric cancer stemness
Gastric cancer (GC) stem cells (GCSCs) are characterized as high level of ALDH activity, however, the mechanisms of maintenance of high ALDH activity and stemness in GCSCs are largely unknown. Here, we report that KDM4C, a H3K9me2/3-demethylase, epigenetically regulates ALDH1A3 by histone demethylat...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023455 | Pride
Itraq quantitative proteomics Cancer stem cells Gastric cancer Aldh1a3 Kdm4c 
ProteomicsKDM4C histone demethylase connects chromatin remodeling and metabolism in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a highly aggressive disease with inferior prognosis necessitating the discovery of novel actionable targets. Here, we show that KDM4C, a histone demethylase amplified in a subset of TNBC, is a driver of TNBC tumor growth. Integrative multi-omic analysis demons...
ORGANISM(S): Homo sapiens (Human) 
2025-04-12 | PXD031768 | Pride
Kdm4c Triple negative breast cancer Histone tail clipping Cathepsin l Grhl2 
TranscriptomicsGene expresion changes following knockdown of KDM4C in primary fibroblasts
Epigenetic and genetic regulations are sometimes considered as separate mechanisms that influence gene expression and phenotypes. However, there are DNA sequence variants in epigenetic regulators that could affect gene regulation. The histone demethylase, KDM4C, promotes transcriptional activation...
ORGANISM(S): Homo sapiens 
2013-09-14 | E-GEOD-41040 | biostudies-arrayexpress
TranscriptomicsTargeting epigenetic networks mediated by Prmt1 and Kdm4c in acute myeloid leukemia
Transcriptional deregulation plays a major role in acute myeloid leukemia, identification of epigenetic modifying enzymes essential for the maintenance of oncogenic transcription programs holds the key to better understanding the biology and designing effective therapeutic strategies for the disease...
ORGANISM(S): Mus musculus 
2016-01-14 | E-MTAB-3322 | biostudies-arrayexpress
GenomicsSAS cell line KDM4C-CUT&Tag sequencing
SAS cell line KDM4C-CUT&Tag sequencing
PRJNA1142017 | ENA
TranscriptomicsThe Demethylase JMJD2C/KDM4C Localizes to H3K4me3 Positive Transcription Start Sites (Affymetrix microarray analysis)
We have mapped transcriptional changes after depletion of the histone demethylases JMJD2C/GASC1/KDM4C and JMJD2A/KDM4A alone or in combination in the esophageal squamous carcinoma cell line, KYSE150. The KYSE150 cell line contains an amplification of the JMJD2C locus. RNA was extracted from KYSE150 ...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-53892 | biostudies-arrayexpress
GenomicsSAS cell line KDM4C-CUT&Tag sequencing
This study explores the role of KDM4C, a histone lysine demethylase, in the development of head and neck squamous cell carcinoma (HNSCC). KDM4C is responsible for removing methyl groups from H3K9me3/2, a modification of histone proteins that can influence gene expression. To examine the distribution...
ORGANISM(S): Homo sapiens 
2025-04-30 | GSE273500 | GEO
GenomicsKDM4C silencing inhibits cell migration and enhances radiosensitivity by upregulating CXCL2 in hepatocellular carcinoma
KDM4C silencing inhibits cell migration and enhances radiosensitivity by upregulating CXCL2 in hepatocellular carcinoma
PRJNA785182 | ENA
UnknownKDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism.
Not available
S-EPMC4731315 | biostudies-literature
GenomicsUSP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGFβ2 transcription
USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGFβ2 transcription
PRJNA562502 | ENA
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