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ProteomicsKDM4C epigenetically regulates and forms a feed-forward loop with ALDH1A3 to maintain gastric cancer stemness
Gastric cancer (GC) stem cells (GCSCs) are characterized as high level of ALDH activity, however, the mechanisms of maintenance of high ALDH activity and stemness in GCSCs are largely unknown. Here, we report that KDM4C, a H3K9me2/3-demethylase, epigenetically regulates ALDH1A3 by histone demethylat...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023455 | Pride
Itraq quantitative proteomics Cancer stem cells Gastric cancer Aldh1a3 Kdm4c 
GenomicsSelective inhibition of ALDH1A3 impedes breast cancer growth and metastasis by blocking ALDH1A3-driven transcriptional programs
Selective inhibition of ALDH1A3 impedes breast cancer growth and metastasis by blocking ALDH1A3-driven transcriptional programs
PRJNA1242824 | ENA
GenomicsALDH1a3 inhibitor effects on Breast cancer Cells Transcriptome
ALDH1a3 inhibitor effects on Breast cancer Cells Transcriptome
PRJNA1082280 | ENA
ProteomicsApplication of folding stability-based proteomics to profile cancer drug
Covalent inhibitors offer powerful therapeutic advantages but require comprehensive profiling to define their on- and off-target activities. Here, we apply two stability-based proteomic methods, SPROX and TPP, to characterize protein targets of the KRASG12C inhibitor ARS-1620 in H358 cell lysate. Bo...
ORGANISM(S): Homo sapiens (Human) 
2026-05-08 | PXD070862 | Pride
ProteomicsProteomics Analysis of Human Mesenchymal Stromal/Stem Cell Sarcomagenesis Model Identifies ALDH1A3 and CD99 as Potential Targets in the Transformation Process
Mesenchymal stromal/stem cells (MSC) may represent the cell-of-origin for sarcoma development. A collection of human MSCs sequentially mutated with an increasing number of oncogenic hits served to recreate a step-wise process of sarcomagenesis. To identify potential protein targets of interest in th...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069892 | Pride
Msc-sarcoma model Sarcomagenesis Cd99 Proteomics (lc-ms/ms) Aldh1a3 
TranscriptomicsALDH1A3-mediated gene expression in MDA-MB-231 cells and MDA-MB-468 cells
To determine the effect ALDH1A3 expression on global gene expression in MDA-MB-231 cells and MDA-MB-468 cells In MDA-MB-231 cells, ALDH1A3 was overexperssed (have low endogenous levels of ALDH1A3) and compared to MSCV empty vector control. In MDA-MB-468 cells that have high endogenous levels of ALDH...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-49322 | biostudies-arrayexpress
TranscriptomicsSelective inhibition of ALDH1A3 impedes breast cancer growth and metastasis by blocking ALDH1A3-driven transcriptional programs
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated with poor survival outcomes. Aldehyde dehydrogenase 1A3 (ALDH1A3) promotes tumor growth, metastasis, and chemoresistance across multiple cancer types including TNBC, glioblastoma, melanoma lung, and colon cance...
ORGANISM(S): Homo sapiens 
2026-01-28 | GSE293106 | GEO
ProteomicsA specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells
Elevated aldehyde dehydrogenase (ALDH) activity correlates with poor outcome for many solid tumors as ALDHs potentially regulate cell proliferation and chemoresistance of cancer stem cells (CSCs). Accordingly, potent and selective inhibitors of key ALDHs may represent a novel CSC-directed treatment ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028125 | Pride
Human Cancer Target-id Small molecule 
GenomicsGenetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure
Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure
PRJNA901979 | ENA
GenomicsExpression data from glioma stem cells (GSC), comparing the WT cells to those after ALDH1A3-KO
Expression data from glioma stem cells (GSC), comparing the WT cells to those after ALDH1A3-KO
PRJNA769119 | ENA
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