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ProteomicsCompetitive target ID for inhibitor NK192
Competitive target ID for inhibitor NK192. To this end the inhibitor was decorated with biotin and used in a pull-down experiment to pull out the desired on-target (USP7) and possible off-targets. The samples were analysed by LC-MS.
ORGANISM(S): Homo sapiens (Human) 
2026-04-21 | PXD063889 | Pride
Usp7 Lc-ms Pull-down 
MetabolomicsMetabolomics reveals molecular signatures for psoriasis biomarkers and drug targets discovery
Psoriasis is a chronic skin disease that affects multiple systems and can be influenced by immunological, environmental, and genetic factors. The discovery of plasma biomarkers of psoriasis and the regulation of metabolic pathways helps us understand psoriasis and may assist clinicians in the diagno...
2024-09-26 | MTBLS5185 | MetaboLights
UnknownId-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target.
Not available
S-EPMC3594064 | biostudies-literature
TranscriptomicsSYK Is a Critical Regulator of FLT3 In Acute Myeloid Leukemia
Cooperative dependencies between mutant oncoproteins and wild-type proteins are critical in cancer pathogenesis and therapy resistance. Although spleen tyrosine kinase (SYK) has been implicated in hematologic malignancies, it is rarely mutated. We used kinase activity profiling to identify collabora...
ORGANISM(S): Homo sapiens 
2014-01-15 | E-GEOD-54065 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human differentiated vs. undifferentiated SH-SY5Y cells transfected with a MeCP2 (transcriptional repressor) decoy to investigate the neurodevelopmental disorder Rett syndrome
Rett syndrome (RTT) is an X-linked dominant neurodevelopmental disorder caused by mutations in MECP2, encoding methyl-CpG-binding protein 2. MeCP2 is a transcriptional repressor elevated in mature neurons and is predicted to be required for neuronal maturation by regulating multiple target genes. Id...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4600 | biostudies-arrayexpress
Genomics
SLC-CRISPRa screen for CDg16 target ID
PRJNA516962 | ENA
GenomicNEI Age-Related Eye Disease Study (AREDS)

The Age-Related Eye Disease Study (AREDS) was initially designed as a long-term multi-center, prospective study of the clinical course of age-related macular degeneration (AMD) and age-related cataract. In addition to collecting natural history data, AREDS included a clinical trial of high-dose ...

phs000001 | dbGaP
MetabolomicsGNPS - MSKCC Target ID T. cruzi
Infected C2C12 myocytes and free T. cruzi parasites were treated with varying doses of an experimental compound from MKSCC for different timepoints, with the goal of identifying metabolome changes caused by the drug treatment.
ORGANISM(S): Trypanosoma Cruzi (ncbitaxon:5693) Mus Musculus (ncbitaxon:10090) 
MSV000080142 | GNPS
TranscriptomicsGenome-wide expression profiling of 4T1 cells to identify genes that are regulated by Id1 and Id3 in breast cancer
By combining RNAi-mediated knockdown of Id1 and Id3 in an aggressive mouse breast cancer cell line (4T1 cells) with genome-wide expression profiling, we identified several new Id target genes and novel pathways regulated by Id.
ORGANISM(S): Mus musculus 
2020-10-31 | GSE129790 | GEO
TranscriptomicsInhibitors of Differentiation-1 Promotes Transformation of Human Papillomavirus Type 16-immortalized Cervical Epithelial Cells
Our previous study implied a correlation of inhibitors of differentiation-1 (Id-1) to cervical cancer development. However, how Id-1 contributes to cervical carcinogenesis is unknown. In the present study, we investigated the role of Id-1 in transforming cervical cells with an in vitro transformatio...
ORGANISM(S): Homo sapiens 
2013-05-11 | GSE46842 | GEO
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