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ProteomicsCD99-mediated immunological synapse formation potentiates CAR-T cell function
Cross-talks between actin and microtubules underly various cellular processes. Using immune synapse model and via cytoskeleton dynamics analyses, here, we demonstrate that CD99 is critical for the actin and microtubule cross-talks and the coordinated reorganization, mediating their physical linkage ...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-18 | PXD039955 | Pride
Immunology Cd99 
ProteomicsProteolytic processing of CD99
The adhesion molecule CD99 is essential for transendothelial migration (TEM) of leukocytes. Here we demonstrate by biochemical and cellular assays that CD99 undergoes ectodomain shedding by the metalloprotease meprin ? and subsequent intramembrane proteolysis by ?-secretase. The cleavage site in CD9...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080746 | MassIVE
ProteomicsProteolytic processing of CD99
The adhesion molecule CD99 is essential for transendothelial migration (TEM) of leukocytes. Here we demonstrate by biochemical and cellular assays that CD99 undergoes ectodomain shedding by the metalloprotease meprin β and subsequent intramembrane proteolysis by γ-secretase. The cleavage site in CD9...
ORGANISM(S): Homo sapiens (Human) 
2017-01-02 | PXD005428 | Pride
Adhesion molecule Tem Inflammation Cell migration Protease Proteolysis 
TranscriptomicsCD99 is a novel prognostic stromal marker in non-small cell lung cancer
The delicate interaction between cancer cells and the surrounding stroma plays an essential role in all stages of tumourigenesis. Despite the significance of this interplay, alterations in protein composition underlying tumour-stroma interactions are largely unknown. The aim of this study was to ide...
ORGANISM(S): Homo sapiens 
2012-06-05 | E-GEOD-33363 | biostudies-arrayexpress
TranscriptomicsExosomes from CD99-deprived Ewing sarcoma cells reverse tumor malignancy
We evaluated the miRNA content of CD99pos EXOs isolated from the parental cell line TC-71 (three samples) and of CD99neg EXOs isolated from TC-CD99-shRNA cells (four samples) by microarray analysis.
ORGANISM(S): Homo sapiens 
2019-07-01 | E-MTAB-7585 | biostudies-arrayexpress
ProteomicsCD99 modulates the proteomic landscape of Ewing sarcoma cells and related-extracellular vesicles.
Ewing sarcoma (EWS) is an aggressive pediatric bone tumor characterized by unmet clinical needs and an incompletely understood epigenetic heterogeneity. Here we considered CD99, a major surface molecule hallmark of EWS malignancy. Fluctuations of CD99 expression strongly impair cell dissemination, d...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD046846 | Pride
Ewing sarcoma  heterogeneity  proteomic  mass spectrometry  biomarkers  extracellular vesicles. 
ProteomicsProteomics Analysis of Human Mesenchymal Stromal/Stem Cell Sarcomagenesis Model Identifies ALDH1A3 and CD99 as Potential Targets in the Transformation Process
Mesenchymal stromal/stem cells (MSC) may represent the cell-of-origin for sarcoma development. A collection of human MSCs sequentially mutated with an increasing number of oncogenic hits served to recreate a step-wise process of sarcomagenesis. To identify potential protein targets of interest in th...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069892 | Pride
Msc-sarcoma model Sarcomagenesis Cd99 Proteomics (lc-ms/ms) Aldh1a3 
GenomicsDevelopment of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma
Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma
PRJNA1235273 | ENA
TranscriptomicsCD99 inhibits neural differentiation of human Ewing sarcoma cells
Ewing sarcoma (EWS) is an aggressive bone tumor of uncertain cellular origin. CD99 is a membrane protein that is expressed in most cases of EWS, although its function in the disease is unknown. Here we have shown that endogenous CD99 expression modulates EWS tumor differentiation and malignancy. We ...
ORGANISM(S): Homo sapiens 
2010-03-08 | GSE10993 | GEO
UnknownTargeting Tumor Vascular CD99 Inhibits Tumor Growth.
Not available
S-EPMC6455290 | biostudies-literature
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