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GenomicsEffect of depletion of PERK on gene expression in T cells after polyclonal or allogeneic stimulation
Effect of depletion of PERK on gene expression in T cells after polyclonal or allogeneic stimulation
PRJNA1320635 | ENA
TranscriptomicsEffect of depletion of PERK on gene expression in T cells after polyclonal or allogeneic stimulation
PERK differentially regulates T cell allogeneic and anti-tumor responses. To further elucidate the mechanism, we performed transcriptomics analyses via bulk RNA sequencing on WT and PERK-deficient T cells after polyclonal or allogeneic stimulation. We here report that endoplasmic reticulum-associate...
ORGANISM(S): Mus musculus 
2025-09-16 | GSE307389 | GEO
ProteomicsChanges in bovine Lymphocyte proteome after stimulation with pokeweed mitogen
A new vaccine against bovine viral diarrhea (BVD) induced unwanted immune reactions with production of alloreactive antibodies in 5–10% of vaccinated cows. Transfer of these antibodies via colostrum caused bovine neonatal pancytopenia (BNP) in calves, with a lethality rate of 90%. The exact immunolo...
ORGANISM(S): Bos taurus (Bovine) 
2022-02-10 | PXD017350 | Pride
Pokeweed mitogen  polyclonal cell stimulation  immune reaction Cow 
TranscriptomicsRNA-seq of isolated primary human CD8+ T cells treated with KDACi with polyclonal stimulation for 6 days
Lysine deacetylase inhibitors (KDACi) show immunomodulatory properties, promoting differentiation of an IL7RhiPD1lo memory precursor (MPEC) phenotype on polyclonal stimulation in vitro and enhancing functional memory responses during infection or immunisation in vivo. We isolated (MACS positive sele...
ORGANISM(S): Homo sapiens 
2024-09-01 | E-MTAB-13366 | biostudies-arrayexpress
TranscriptomicsATAC-seq of isolated primary human CD8+ T cells treated with KDACi with polyclonal stimulation for 6 days
Lysine deacetylase inhibitors (KDACi) show immunomodulatory properties, promoting differntiation of an IL7RhiPD1lo memory precursor (MPEC) phenotype on polyclonal stimulation in vitro and enhancing functional memory responses during infection or immunisation in vivo. We isolated (MACS positive selec...
ORGANISM(S): Homo sapiens 
2024-09-01 | E-MTAB-13367 | biostudies-arrayexpress
ProteomicsEndoC-betaH3 Cell FANCA Protein Interactions Regulated by Glucose Stimulation
Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. Therefore, we sought to identify previously unexplored rol...
ORGANISM(S): Homo sapiens (Human) 
2019-07-25 | PXD010589 | Pride
Human Pancreas beta cell Glucose stimulation 
ProteomicsAltered porcine PBMC proteome and secretome after stimulation with BanLec
With this experiment, we aimed at showing changes in the proteome and secretome of porcine peripheral blood mononuclear cells (PBMC) after stimulation with Banana Lectin (BanLec).
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-08-26 | PXD027505 | Pride
Pbmc Musa banana Polyclonal cell stimulation Banlec Plant lectin Pig Lc-ms/ms 
UnknownIL-21 in Conjunction with Anti-CD40 and IL-4 Constitutes a Potent Polyclonal B Cell Stimulator for Monitoring Antigen-Specific Memory B Cells.
Not available
S-EPMC7072853 | biostudies-literature
UnknownIdentification and characterization of polyclonal αβ-T cells with dendritic cell properties.
Not available
S-EPMC3528357 | biostudies-literature
TranscriptomicsTranscript profile comparison of Zbtb20-sufficient and Zbtb20-deficient polyclonal bone marrow plasma cells
ZBTB20 is an adjuvant-specific factor for long-term antibody responses. This factor is critical for maintaining long-lived plasma cells in alum-adjuvanted antibody responses but is dispensable for TLR ligand-adjuvanted responses. To identify the functions of ZBTB20 in long-lived plasma cells, we per...
ORGANISM(S): Mus musculus 
2014-06-19 | E-GEOD-58659 | biostudies-arrayexpress
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