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ProteomicsDynamic protein interactions of the Polycomb Repressive Complex 2
Polycomb proteins assemble to form complexes with important roles in epigenetic regulation. The Polycomb Repressive Complex 2 (PRC2) modulates the di- and tri-methylation of lysine 27 on histone H3, each of which are associated with gene repression. Although three subunits, EZH1/2, SUZ12 and EED, fo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080739 | MassIVE
GenomicsDirect Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors (ChIP-Seq)
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study, we show that Bmi1, a core component of Polycomb Repressive Complex 1 (PRC1), binds direct...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-33653 | biostudies-arrayexpress
TranscriptomicsGenome-wide Identification of Polycomb Target Genes Reveals a Functional Association of Pho with Scm in Bombyx mori
Polycomb group (PcG) proteins are involved in chromatin modifications for maintaining gene repression that play important roles in the regulation of gene expression, tumorigenesis, chromosome X-inactivation, and genomic imprinting in Drosophila melanogaster, mammals, and even plants. PcG proteins ac...
ORGANISM(S): Bombyx mori 
2012-04-17 | E-GEOD-34246 | biostudies-arrayexpress
TranscriptomicsOpposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells
Polycomb group (PcG) proteins are transcriptional repressors with a central role in the establishment and maintenance of gene expression patterns during development. We have investigated the role of Polycomb Repressive Complexes (PRCs) in hematopoietic stem cells (HSCs) and progenitor populations. W...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-21404 | biostudies-arrayexpress
TranscriptomicsFrequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line
Epigenetic reprogramming is commonly observed in cancer, and is hypothesized to involve multiple mechanisms, including DNA methylation and Polycomb repressive complexes (PRCs). Here we devise a new experimental and analytical strategy using customized high density tiling arrays to investigate coordi...
ORGANISM(S): Homo sapiens 
2008-08-07 | E-GEOD-12334 | biostudies-arrayexpress
GenomicsKDM2B binds CpG islands and modulates recruitment of Ring1b
CpG island elements are associated with most mammalian gene promoters, yet how they contribute to gene regulation remains poorly understood. Recently it has become clear that a subset of CpG islands in embryonic stem cells can act as polycomb response elements and are recognized by the polycomb sile...
ORGANISM(S): Mus musculus 
2012-12-26 | E-GEOD-40860 | biostudies-arrayexpress
GenomicsDeletion of RING1A/B and loss of H2AK119ub1 affects PRC2 occupancy and H3K27me3 genome-wide
The chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and development. However, the mechanisms by which these complexes recognize their target sites and function together to form repressive chro...
ORGANISM(S): Mus musculus 
2014-05-27 | E-GEOD-55697 | biostudies-arrayexpress
TranscriptomicsCoordinated regulation of polycomb group complexes through microRNAs in cancer
To determine the altered mRNA expression signatures upon overexpressing EZH2 regulated microRNAs in cancer. To identify EZH2 regulated microRNAs in cancer. Two-condition experiment: Each EZH2 microRNA was overexpressed and compared to a control RNA in BT549 breast cancer cells. In DU145 prostate can...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-26996 | biostudies-arrayexpress
TranscriptomicsKDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2012-12-26 | E-GEOD-41267 | biostudies-arrayexpress
TranscriptomicsThe Polycomb protein Pcgf2/Mel18 regulates mesoderm cell fate-specification of embryonic stem cells through multiple mechanisms
Polycomb complexes are essential regulators of stem cell identity, yet very little is known about their molecular mechanisms during cell differentiation. Pcgf proteins (Pcgf1/2/3/4/5/6) are core subunits of the Polycomb repressive complex 1 (PRC1). It has been recently proposed that specific Pcgf pr...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-67868 | biostudies-arrayexpress
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