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MetabolomicsNew insights into the responses of soil microorganisms to polycyclic aromatic hydrocarbon stress by combining enzyme activity and sequencing analysis with metabolomics
Polycyclic aromatic hydrocarbons (PAHs), some of the most widespread organic contaminants, are highly toxic to soil microorganisms. Whether long-term polluted soils can still respond to the fresh input of pollutants is unknown. In this study, the soil enzyme activity, soil microbial community struct...
2021-02-17 | MTBLS1196 | MetaboLights
TranscriptomicsStructurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. These multi-ring chemicals differentially activate the Aryl Hydrocarbon Receptor (AHR) in a structurally-dependent manner, and induce toxicity via both AHR-dependent...
ORGANISM(S): Danio rerio 
2013-05-15 | E-GEOD-44130 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of zebra fish liver after water-borne exposure to polycyclic aromatic hydrocarbons and alkylphenols
Effect of 5.4 ppm polycyclic aromatic hydrocarbons (PAHs) and 18.2 ppm alkylphenols (APs) on gene expression in adult Zebrafish (Danio rerio) liver after 1 and 7 weeks of water-borne exposure.
ORGANISM(S): Danio rerio 
2008-12-11 | E-MEXP-1685 | biostudies-arrayexpress
TranscriptomicsHepG2 treated with Polycyclic Aromatic Hydrocarbons (PAHs)
Assessing the potential carcinogenicity of human toxins represents an ongoing challenge. Chronic rodent bioassays predict human cancer risk with limited reliability, and are expensive and time-consuming. To identify alternative prediction methods, we evaluated a transcriptomics-based human in vitro ...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-37326 | biostudies-arrayexpress
ProteomicsInduction of active hepatic cytochrome P450 enzymes in mice exposed to benzo[a]pyrene or environmental mixtures of polycyclic aromatic hydrocarbons
Cytochrome P450 enzymes play an important role in bioactivating or detoxifying polycyclic aromatic hydrocarbons (PAHs). We exposed mice to doses of benzo[a]pyrene (BaP) or a mixture of PAHs to characterize dose- and time-response relationships of specific cytochrome P450s. Mice exposed to the highes...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD019472 | Pride
Enyzme induction Chemoproteomics Polycyclic aromatic hydrocarbons Cytochrome p450 
TranscriptomicsHepG2 treated with two Polycyclic Aromatic Hydrocarbons (benzo[a]anthracene & benzo[k]fluoranthene)
To gain deeper insight into the mechanism of toxicity, it is important to identify and characterize miRNAs profiles involved in responses to specific classes of toxicants in conjunction with their impact on gene expression levels. However, few reports have described the effects of toxicants on miRNA...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-49068 | biostudies-arrayexpress
TranscriptomicsHepG2 treated with Polycyclic Aromatic Hydrocarbons (PAHs)
Assessing the potential carcinogenicity of human toxins represents an ongoing challenge. Chronic rodent bioassays predict human cancer risk with limited reliability, and are expensive and time-consuming. To identify alternative prediction methods, we evaluated a transcriptomics-based human in vitro ...
ORGANISM(S): Homo sapiens 
2012-04-18 | GSE37326 | GEO
TranscriptomicsTranscription profiling of mouse keratinocytes expressing AhR to investigate inflammatory responses
Occupational and environmental exposure to polycyclic aromatic hydrocarbons (PAHs) has been suggested to provoke inflammatory and/or allergic disorders including asthma, rhinitis and dermatitis. The molecular mechanisms of this PAH-mediated inflammation remain to be clarified. Previous studies imp...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2955 | biostudies-arrayexpress
ProteomicsSurfactants regulate the function and structure of transmembrane protein of Bacillus cereus——promote transmembrane transport of polycyclic aromatic hydrocarbons (PAHs)
Polycyclic Aromatic Hydrocarbons (PAHs) can be degraded by its highly efficient degrading bacteria, Bacillus cereus. The transmembrane transport is very important in the process of PAHs adsorption, uptake, transmembrane transport, and degradation by Bacillus cereus. Surfactants are the key substance...
ORGANISM(S): Bacillus Cereus Atcc 14579 
2020-03-21 | PXD018137 |
TranscriptomicsResponse of Arabidopsis thaliana to phenanthrene
Background: Polycyclic aromatic hydrocarbons (PAHs) are toxic, widely-distributed, environmentally persistent, and carcinogenic byproducts of carbon-based fuel combustion. Previously, plant studies have shown that PAHs induce oxidative stress, reduce growth, and cause leaf deformation as well as ti...
ORGANISM(S): Arabidopsis thaliana 
2010-04-27 | E-GEOD-20009 | biostudies-arrayexpress
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