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MetabolomicsUntargeted gas chromatography–mass spectrometry-based metabolomics analysis of kidney and liver tissue from the Lewis Polycystic Kidney rat
Polycystic kidney disease (PKD) encompasses a spectrum of inherited disorders that lead to end-stage renal disease (ESRD). There is no cure for PKD and current treatment options are limited to renal replacement therapy and transplantation. A better understanding of the pathobiology of PKD is needed ...
2023-01-26 | MTBLS748 | MetaboLights
MetabolomicsDissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by loss-of-function mutations in PKD1 or PKD2. Increased glycolysis is a prominent feature of the disease, but how it impacts on other metabolic pathways is unknown. Here, we present an analysis of mouse Pkd1 mutant ce...
2019-06-07 | MTBLS677 | MetaboLights
TranscriptomicsExpression data from renal cysts of autosomal dominant polycystic kidney disease (ADPKD) patients
To elucidate the molecular pathways that modulate renal cyst growth in autosomal dominant polycystic kidney disease (ADPKD) Keywords: Disease state analysis We performed global gene profiling on renal cysts of different size (small cysts: less than 1 ml, n=5; medium cysts: between 10-25 ml, n=5; lar...
ORGANISM(S): Homo sapiens 
2009-08-14 | E-GEOD-7869 | biostudies-arrayexpress
GenomicsAn efficient and comprehensive strategy for genetic diagnostics of polycystic kidney disease
We established and validated sequence capture based NGS testing approach for all genes known for cystic and polycystic kidney disease including PKD1. This setup overcomes the complication of unspecific capture of pseudogenes by applying a mapping algorithm efficiently and specifically aligning reads...
EGAS00001001003 | EGA
TranscriptomicsGlobal gene expression profiling in PPAR-M-NM-3 agonist-treated kidneys in an orthologous rat model of human autosomal recessive polycystic kidney disease
Kidneys are enlarged by aberrant proliferation of tubule epithelial cells leading to the formation of numerous cysts, nephron loss, and interstitial fibrosis in polycystic kidney disease (PKD). Pioglitazone (PIO), a PPAR-M-NM-3 agonist, decreased cell proliferation, interstitial fibrosis and inflamm...
ORGANISM(S): Rattus norvegicus 
2012-03-22 | E-GEOD-35167 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse kidney from Aquaporin-11 knockout effect
Aquaporin-11 (AQP11), a new member of the aquaporin family, is localized in the endoplasmic reticulum (ER). Aqp11–/– mice neonatally suffer from polycystic kidneys derived from the proximal tubule. Its onset is proceeded by the vacuolization of ER. However, the mechanism for the formation of ...
ORGANISM(S): Mus musculus 
2008-10-26 | E-GEOD-10634 | biostudies-arrayexpress
ProteomicsProteomic Analysis of Urinary Extracellular Vesicles
Novel therapies in autosomal dominant polycystic kidney disease (ADPKD) signal the need for markers of disease progression or response to therapy. This study aimed to identify disease-associated proteins in urinary extracellular vesicles (uEVs), which include exosomes, in patients with ADPKD. We per...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080264 | MassIVE
TranscriptomicsGene expression profiling in human ADPKD cell lines
Changes in gene expression levels were identified by microarray. Samples were human kidney epithelial cell lines derived from patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and unaffected controls. Autosomal Dominant Polycystic Kidney Disease (ADPKD), the most common inherited k...
ORGANISM(S): Homo sapiens 
2017-07-05 | E-MTAB-4188 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling in human ADPKD cell lines
Changes in microRNA expression levels were identified by microarray. Samples were human kidney epithelial cell lines derived from patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and unaffected controls. Autosomal Dominant Polycystic Kidney Disease (ADPKD), the most common inherit...
ORGANISM(S): Homo sapiens 
2017-07-05 | E-MTAB-4189 | biostudies-arrayexpress
TranscriptomicsPolycystic Kidney Disease Progression Expression Analysis
Polycystic Kidney Disease (PKD) is a genetic disease of the kidney characterized by the gradual replacement of normal kidney parenchyma by fluid-filled cysts and fibrotic tissue. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is caused by mutations in the PKD1 or PKD2 gene. Here we present an ...
ORGANISM(S): Mus musculus 
2019-12-24 | E-MTAB-8086 | biostudies-arrayexpress
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