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ProteomicsIdentification of Polycystin-1 interacting proteins
Identification of Polycystin-1 interacting proteins after transfection of PC1 in HEK cells
ORGANISM(S): Homo sapiens (Human) 
2024-11-12 | PXD056889 | Pride
Polycystin-1 
UnknownPolycystin-1 Interacting Protein-1 (CU062) Interacts with the Ectodomain of Polycystin-1 (PC1).
Not available
S-EPMC10487028 | biostudies-literature
ProteomicsIdentification of biomarkers for PKD1 using urinary exosomes
Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of ESRD. Affected individuals inherit a defective copy of either the PKD1 or PKD2 gene, encoding the proteins polycystin?1 (PC1) or polycystin?2 (PC2) respectively. PC1 and PC2 are secreted on urinary exosome?like vesicles (ELVs)...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-01 | MSV000079547 | MassIVE
ProteomicsThe C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion
Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent potentially lethal monogenic disorder. Mutations in the PKD1 gene, which encodes polycystin-1 (PC1), account for approximately 78% of cases. PC1 is a large 462-kDa protein that undergoes cleavage in its N and C-terminal domai...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-17 | PXD040210 | Pride
Metabolism Polycystin-1 (pc1) C-terminal tail (ctt) Autosomal dominant polycystic kidney disease (adpkd) Nicotinamide nucleotide transhydrogenase (nnt) Mitochondria 
TranscriptomicsTranscriptome Profiling of UCL93 Kidney Epithelial Cells and CRISPR-Cas9 Knockouts for PKD1 and BICC1 Using Total RNA-Seq
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary cause of kidney failure, resulting from germline mutations in PKD1 and PKD2 in over 90% of cases. Polycystin-1 (PC-1), a cell surface receptor linked to focal adhesion proteins, plays a critical role in regulating cel...
ORGANISM(S): Homo sapiens 
2026-07-27 | E-MTAB-14624 | biostudies-arrayexpress
TranscriptomicsExpression data from renal primary epithelial cells
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of multiple fluid-filled cysts that destroy the kidney architecture resulting in end-stage renal failure. Mutations in the ADPKD genes PKD1 and PKD2 account for nearly all the cases of ADPKD. Increased cell prolif...
ORGANISM(S): Rattus norvegicus 
2010-05-19 | E-GEOD-11500 | biostudies-arrayexpress
UnknownThe Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking.
Not available
S-EPMC4814171 | biostudies-literature
UnknownPolycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex.
Not available
S-EPMC3990174 | biostudies-literature
UnknownIon channel function of polycystin-2/polycystin-1 heteromer revealed by structure-guided mutagenesis.
Not available
S-EPMC12183636 | biostudies-literature
UnknownProtein phosphatase 1α interacts with a novel ciliary targeting sequence of polycystin-1 and regulates polycystin-1 trafficking.
Not available
S-EPMC6704455 | biostudies-literature
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