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ProteomicsIdentification of Polycystin-1 interacting proteins
Identification of Polycystin-1 interacting proteins after transfection of PC1 in HEK cells
ORGANISM(S): Homo sapiens (Human) 
2024-11-12 | PXD056889 | Pride
Polycystin-1 
TranscriptomicsExpression data from renal primary epithelial cells
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of multiple fluid-filled cysts that destroy the kidney architecture resulting in end-stage renal failure. Mutations in the ADPKD genes PKD1 and PKD2 account for nearly all the cases of ADPKD. Increased cell prolif...
ORGANISM(S): Rattus norvegicus 
2010-05-19 | E-GEOD-11500 | biostudies-arrayexpress
UnknownPolycystin-1 Interacting Protein-1 (CU062) Interacts with the Ectodomain of Polycystin-1 (PC1).
Not available
S-EPMC10487028 | biostudies-literature
UnknownThe ion channel function of polycystin-1 in the polycystin-1/polycystin-2 complex.
Not available
S-EPMC6832002 | biostudies-literature
UnknownThe isolated polycystin-1 COOH-terminal can activate or block polycystin-1 signaling.
Not available
S-EPMC2039907 | biostudies-literature
TranscriptomicsTranscriptome Profiling of UCL93 Kidney Epithelial Cells and CRISPR-Cas9 Knockouts for PKD1 and BICC1 Using Total RNA-Seq
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary cause of kidney failure, resulting from germline mutations in PKD1 and PKD2 in over 90% of cases. Polycystin-1 (PC-1), a cell surface receptor linked to focal adhesion proteins, plays a critical role in regulating cel...
ORGANISM(S): Homo sapiens 
2026-07-27 | E-MTAB-14624 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of ADPKD placentas
The goal of this microarray study was to determine genes whose transcriptional profile was altered in the absence of polycystin-1 expression. Placentas from knockout and wild-type littermates were compared at the latest viable timepoints (14.5d and 15.5dpc) and genes with a fold change > 1.5 were i...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-2673 | biostudies-arrayexpress
UnknownProtein phosphatase-1α interacts with and dephosphorylates polycystin-1.
Not available
S-EPMC3366979 | biostudies-literature
UnknownThe Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking.
Not available
S-EPMC4814171 | biostudies-literature
UnknownNek8 regulates the expression and localization of polycystin-1 and polycystin-2.
Not available
S-EPMC2391053 | biostudies-literature
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