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TranscriptomicsGene Expression Profiling in Polycythemia Vera (PV)
To define the molecular abnormalities at the stem cell level in polycythemia vera (PV), we examined global gene expression in circulating CD34+ cells from 19 JAK2 V617F-positive PV patients and 6 normal individuals using Affymetrix oligonucleotide microarray technology. We observed that CD34+ cell g...
ORGANISM(S): Homo sapiens 
2014-08-29 | E-GEOD-47018 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of normal and JAK2V617F-positive erythroblasts of polycythemia vera and essential thrombocythemia
This experiment was designed to identify genes differentially expressed in association with the JAK2V617F mutation in polycythemia vera (PV) and essential thrombocythemia (ET). Peripheral blood was obtained from 20 ET and 16 PV patients and erythroid progenitors were grown in semi-solid methylcellul...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-MTAB-384 | biostudies-arrayexpress
TranscriptomicsChanges of miRNA expression in granulocytes of patients with polycythemia vera (PV) and essential thrombocythemia (ET) receiving INCB018424 in a Phase 2 study
A global microRNA expression profile was obtained from gradient-purified granulocytes (>95% pure) collected at the time of screening and at cycle 4 of treatment Protocol #18424-256 is a Phase 2 study of the JAK1 and JAK2 inhibitor INCB01842 in patients with advanced polycythemia vera (PV) and essent...
ORGANISM(S): Homo sapiens 
2012-09-26 | E-GEOD-32194 | biostudies-arrayexpress
ProteomicsInvestigating the proteome of red blood cells and reticulocytes in Polycythemia Vera and Essential Thrombocythemia
The project aims at comparing the effect of the JAK2V617F mutation on protein expression in human erythroid cells in the context of Polycythemia Vera and Essential Thrombocythemia
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD029965 | Pride
Reticulocytes Human red blood cells Erythrocytes Polycythemia vera Nlc-ms/ms Orbitrap fusion Essential thrombocythemia Jak2v617f 
ProteomicsProteome in human hematopoietic stem and progenitor cell subpopulations from polycythemia vera patients and controls
Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) characterized by hyper-proliferation of the erythroid, megakaryocytic and granulocytic lineages and the presence of an activating mutation in JAK2. To elucidate mechanisms that regulate PV stem cells, we applied a newly developed data-ind...
ORGANISM(S): Homo sapiens (Human) 
2022-01-19 | PXD021178 | Pride
Human Polycythemia vera Hematopoietic stem and progenitor cell subpopulations 
ProteomicsQuantitative Analysis of the erythrocyte membrane proteins in polycythemia vera patients treated with hydroxycarbamide
Polycythemia vera (PV) is a myeloproliferative disorder arising in pluripotent stem cells that causes an abnormal erythrocyte mass. More than 90% of PV patients have a mutation in JAK2 protein that is closely associated with the erythrocyte membrane. We report findings on quantitative analysis of th...
ORGANISM(S): Homo sapiens (Human) 
2015-05-11 | PXD001532 | Pride
Polycythemia vera Erythrocyte membrane associated proteins Jak2 v617f Lc-ms/ms 
GenomicsEGAS00001000028-sc-20120222 - samples
Polycythemia Vera Myeloproliferative Disease exome sequencing
EGAD00001000123 | EGA
GenomicsTFPI from Erythroblasts Drives Heme Production in Central Macrophages Promoting Erythropoiesis in Polycythemia Vera
TFPI from Erythroblasts Drives Heme Production in Central Macrophages Promoting Erythropoiesis in Polycythemia Vera
PRJNA933340 | ENA
UnknownTwo clinical phenotypes in polycythemia vera.
Not available
S-EPMC4211877 | biostudies-literature
ProteomicsComparison of proteome composition of serum enriched in extracellular vesicles isolated from polycythemia vera patients and healthy controls
Extracellular vesicles (EVs), e.g., exosomes and microvesicles, are one of the main networks of intercellular communication. In myeloproliferative disorders, such as polycythemia vera (PV), excess of EVs originating from overabundant blood cells can directly contribute to thrombosis through their pr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-06-29 | MSV000098375 | MassIVE
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