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MetabolomicsPolyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans
Protection against pathogens is a major function of the gut microbiota. Although bacterial natural products have emerged as crucial components of host-microbiota interactions, their exact role in microbiota-mediated protection is largely unexplored. We addressed this knowledge gap with the nematode ...
2025-05-06 | MTBLS8694 | MetaboLights
MetabolomicsPolyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans

Protection against pathogens is a major function of the gut microbiota. Although bacterial natural products have emerged as crucial components of host-microbiota interactions, their exact role in microbiota-mediated protection is largely unexplored. We addressed this knowledge gap with the nemato...

2025-05-27 | MTBLS8440 | MetaboLights
MetabolomicsMapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
Polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) hybrid systems typically use complex protein-protein interactions to facilitate direct transfer of intermediates between these multimodular megaenzymes. In the canal-associated neurons (CANs) of Caenorhabditis elegans, PKS-1 and NR...
2021-06-22 | MTBLS2313 | MetaboLights
ProteomicsProgrammable polyketide biosynthesis platform for production of aromatic compounds in yeast
To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms are required. Here we present a novel yeast platform for bi...
ORGANISM(S): Saccharomyces Cerevisiae 
2020-02-11 | PXD013388 | panorama
ProteomicsRetrobiosynthesis of unnatural lactams via reprogrammed polyketide synthase
Using discovery global proteomics to study the retrobiosynthesis of unnatural lactams via reprogrammed polyketide synthase.
ORGANISM(S): Pseudomonas Putida Kt2440 (ncbitaxon:160488) 
2025-01-28 | MSV000096981 | MassIVE
ProteomicsStructure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13
Mycobacterium polyketide synthase 13 (Pks13) is a protein complex comprised of a closely symmetric parallel dimer of chains, each encoding several enzymatic and transport functions. This module carries out the condensation of two different very long chain fatty acids to produce mycolic acids that ar...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2023-06-13 | PXD033471 | Pride
Xl-ms Dsso Polyketide synthase pks13 Mycobacterium 
GenomicsPolyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens inC. elegans
Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens inC. elegans
PRJNA1027780 | ENA
TranscriptomicsColon tissue of Il10-/- mice monoassociated with Escherichia coli NC101 or NC101-delta-pks
We observed that deletion of polyketide synthase (pks) from E. coli NC101 reduces its ability to induce tumors in interleukin-10 knockout (Il10-/-) mice injected with azoxymethane (AOM), without altering histologic inflammation. The goal of this experiment is to assess inflammatory cytokine levels i...
ORGANISM(S): Mus musculus 
2012-07-04 | E-GEOD-39095 | biostudies-arrayexpress
TranscriptomicsStudies on the production of fungal polyketides in Aspergillus nidulans using systems biology tools
Using genetic engineering tools available for the model organism Aspergillus nidulans, we constructed two recombinant strains; one expressing the model polyketide Penicillium griseofulvum 6-methylsalicylic acid (6-MSA) polyketide synthase gene, and one expressing the 6-MSA gene and overexpressing th...
ORGANISM(S): Emericella nidulans 
2009-02-27 | E-GEOD-12859 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing of small RNAs associated with Chalcone Synthase A (CHS-A) sense cosuppression in petunia
We report the application of sequencing-by-synthesis technology for high-throughput profiling of small RNAs involved in Chalcone synthase A (CHS-A) sense cosuppression in petunia. Sense cosuppression is a classical form of eukaryotic post-transcriptional gene silencing. It was first reported in tran...
ORGANISM(S): Petunia x hybrida 
2009-09-27 | E-GEOD-13764 | biostudies-arrayexpress
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