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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
TranscriptomicsResponse of Burkholderia cenocepacia to polymyxin B
Response of three strains, K56-2, RSF34, and RSF34 4000B to polymyxin B and baseline changes between the strains
ORGANISM(S): Burkholderia cenocepacia 
2011-06-01 | E-MTAB-720 | biostudies-arrayexpress
MetabolomicsMetabolic Rewiring of Bacterial Subpopulations Governs Polymyxin Responses in Acinetobacter baumannii
Polymyxins are often last-resort antibiotics against high-priority Gram-negative pathogens, particularly Acinetobacter baumannii. However, most mechanistic studies to date have overlooked the heterogeneity within bacterial populations during polymyxin treatment. Using time-lapse imaging and propidiu...
2026-07-27 | MTBLS14745 | MetaboLights
MetabolomicsComparative metabolomics and transcriptomics revealed multiple pathways associated with polymyxin killing in Pseudomonas aeruginosa
Polymyxins are the last-line antibiotics against multidrug-resistant Pseudomonas aeruginosa however, resistance to polymyxins has been increasingly reported. Therefore, understanding the mechanisms of polymyxin activity and resistance is crucial for preserving their clinical usefulness. This study e...
2018-11-14 | MTBLS751 | MetaboLights
MetabolomicsGenome-scale metabolic modelling of responses to polymyxins in Pseudomonas aeruginosa
Background: Pseudomonas aeruginosa often causes multidrug-resistant infections in immunocompromised patients and polymyxins are often used as the last-line therapy. Alarmingly, resistance to polymyxins has been increasingly reported worldwide recently. To rescue this last-resort class of antibiotics...
2018-02-28 | MTBLS630 | MetaboLights
GenomicsTranscriptome of Acinetobacter baumannii ATCC 17978 treated polymyxin B
Transcriptome of Acinetobacter baumannii ATCC 17978 treated polymyxin B
PRJNA686868 | ENA
ProteomicsProteomic response of SK-MEL-2 cells to polymyxin B
SK-MEL-2 cell line belongs to series of melanoma cell lines established from patient-derived tumor samples, which is usually applied in the melanin-related mechanism studies. TMT-labeling quantitative proteomics which is the state-of-art LC-MS/MS technique for protein quantitation, in this study, wa...
ORGANISM(S): Homo sapiens (Human) 
2022-03-22 | PXD030206 | Pride
Human Lc-msms Skin Melanoma cells 
TranscriptomicsE.coli response to Antimicrobial Arylamides
We treated logarithmically growing cultures of E.coli with a sub-lethal dose of an antimicrobial arylamide compound (PMX 10070) and Polymyxin B sulfate to measure transcriptional responses in an effort to understand mechanism of action Treated samples were assayed at time = 20min and time = 60min af...
ORGANISM(S): Escherichia coli 
2011-08-02 | E-GEOD-31140 | biostudies-arrayexpress
GenomicsThe Impact of the CpxA on Regulating Polymyxin B Resistance in Salmonella Typhimurium
The Impact of the CpxA on Regulating Polymyxin B Resistance in Salmonella Typhimurium
PRJNA1182732 | ENA
ProteomicsTranscriptomics and mutagenesis analysis uncover key mechanisms involved in polymyxin B resistance and heteroresistance of the neonatal sepsis pathogen Enterobacter bugandensis
Enterobacter bugandensis is one of species from the E. cloacae complex (ECC) that has been predominantly associated to neonatal sepsis. A major concern with E. bugandensis and ECC bacteria in general is the frequent appearance of multidrug resistant isolates including those resistant to last-resort...
ORGANISM(S): Enterobacter bugandensis 
2024-04-05 | PXD042287 | Pride
Enterobacter bugandensis Polymyxin b resistance 
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