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ProteomicsDecrypting the functional design of unmodified translation elongation factor P
Stalling of ribosomes due to consecutive proline motifs during polypeptide synthesis is a challenge faced by organisms across all kingdoms. To overcome this, bacteria employ translation elongation factor P (EF-P), while archaea and eukaryotes rely on a/eIF5A. Typically, these elongation factors beco...
ORGANISM(S): Weeksella virosa Rhodomicrobium vannielii ATCC 17100 Escherichia coli 
2024-04-08 | PXD044929 | Pride
Post-translational modification Translation elongation factor Ribosome stalling Polyproline-containing proteins 
ProteomicsProteome analysis of Corynebacterium glutamicum ATCC13032 Δefp
Bacterial translational elongation factor P (EF-P) is required during translation of proteins containing consecutive proline motifs. Several transcription and translational regulators contain polyproline motifs and therefore, EF-P might also affect levels of proteins that do not contain polyproline ...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2020-04-06 | PXD014742 | Pride
Ef-p Corynebacterium glutamicum Actinobacteria Elongation factor p 
UnknownDifferential Occurrence of Interactions and Interaction Domains in Proteins Containing Homopolymeric Amino Acid Repeats.
Not available
S-EPMC4683181 | biostudies-literature
UnknownElongated polyproline motifs facilitate enamel evolution through matrix subunit compaction.
Not available
S-EPMC2787623 | biostudies-literature
UnknownGenome-wide analyses and functional classification of proline repeat-rich proteins: potential role of eIF5A in eukaryotic evolution.
Not available
S-EPMC4218817 | biostudies-literature
UnknownQuantifying intramolecular binding in multivalent interactions: a structure-based synergistic study on Grb2-Sos1 complex.
Not available
S-EPMC3192808 | biostudies-literature
UnknownThe human mitochondrial translation factor TACO1 alleviates mitoribosome stalling at polyproline stretches.
Not available
S-EPMC11381339 | biostudies-literature
UnknownHorizontal Gene Transfer of a key Translation Factor and its Role in Polyproline Proteome Evolution.
Not available
S-EPMC11388002 | biostudies-literature
UnknownDiversity of polyproline recognition by EVH1 domains.
Not available
S-EPMC3882067 | biostudies-literature
UnknownHerpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance.
Not available
S-EPMC9494279 | biostudies-literature
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