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ProteomicsMass spectrometry insights into a tandem ubiquitinâ??binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin
Unanchored polyubiquitin chains are emerging as important regulators of cellular physiology with diverse roles paralleling those of substrate-conjugated polyubiquitin. However tools able to discriminate unanchored polyubiquitin chains of different isopeptide linkages have not been described. We desc...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079990 | MassIVE
TranscriptomicsUbb Knockout Mouse Testis
Analysis of Ubb knockout mouse testes at 7, 4, 21, and 28 dpp. Ubiquitin (Ub) is an essential protein found in all eukaryotic cells and plays important roles in a variety of cellular functions including germ cell development. Targeted disruption of the polyubiquitin gene Ubb results in male and fe...
ORGANISM(S): Mus musculus 
2011-02-28 | E-GEOD-27568 | biostudies-arrayexpress
ProteomicsLinkage Reprogramming by Tailor-made E3s Reveals Polyubiquitin Chain Requirements in DNA Damage Bypass
A polyubiquitin chain can adopt a variety of shapes, depending on how the ubiquitin monomers are joined. However, the relevance of linkage for the signaling functions of polyubiquitin chains is often poorly understood because of our inability to control or manipulate this parameter in vivo. Here we ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-04-25 | PXD030735 | Pride
Ubiquitin E3 ligase Dna damage bypass Pcna 
ProteomicsThe Ubiquitin Interacting Motif Like Domain of Met4 is a K48 Polyubiquitin Chain Selective Binding Domain
Publication upload for journal submission 'The Ubiquitin Interacting Motif Like Domain of Met4 is a K48 Polyubiquitin Chain Selective Binding Domain'
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-02 | MSV000086795 | MassIVE
ProteomicsMass spectrometry insights into a tandem ubiquitin‐binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin
Unanchored polyubiquitin chains are emerging as important regulators of cellular physiology with diverse roles paralleling those of substrate-conjugated polyubiquitin. However tools able to discriminate unanchored polyubiquitin chains of different isopeptide linkages have not been described. We desc...
ORGANISM(S): Homo sapiens (Human) 
2016-05-18 | PXD004059 | Pride
Ubiquitin Polyubiquitin 
TranscriptomicsRNAseq of Arabidopsis plants lacking E2 ubiquitin conjugating enzymes UBC35 and UBC36
This RNAseq experiment aims at determining the reprogramming of gene expression upon loss of K63 polyubiquitin chain formation. Twelve-day-old plants expressing a beta-estradiol inducible artificial microRNA targeting the two plant E2 enzymes catalyzing K63 polyubiquitin chain formation were mock-tr...
ORGANISM(S): Arabidopsis thaliana 
2020-01-01 | E-MTAB-8437 | biostudies-arrayexpress
UnknownUbiquitin acetylation inhibits polyubiquitin chain elongation.
Not available
S-EPMC4328746 | biostudies-literature
UnknownDifferent HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis.
Not available
S-EPMC1356336 | biostudies-literature
UnknownLinkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass.
Not available
S-EPMC9098123 | biostudies-literature
UnknownTripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism.
Not available
S-EPMC3605639 | biostudies-literature
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