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ProteomicsMass spectrometry insights into a tandem ubiquitinâ??binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin
Unanchored polyubiquitin chains are emerging as important regulators of cellular physiology with diverse roles paralleling those of substrate-conjugated polyubiquitin. However tools able to discriminate unanchored polyubiquitin chains of different isopeptide linkages have not been described. We desc...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079990 | MassIVE
ProteomicsMass spectrometry insights into a tandem ubiquitin‐binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin
Unanchored polyubiquitin chains are emerging as important regulators of cellular physiology with diverse roles paralleling those of substrate-conjugated polyubiquitin. However tools able to discriminate unanchored polyubiquitin chains of different isopeptide linkages have not been described. We desc...
ORGANISM(S): Homo sapiens (Human) 
2016-05-18 | PXD004059 | Pride
Ubiquitin Polyubiquitin 
UnknownMolecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Not available
S-EPMC5295632 | biostudies-literature
UnknownThe E2-25K ubiquitin-associated (UBA) domain aids in polyubiquitin chain synthesis and linkage specificity.
Not available
S-EPMC3086721 | biostudies-literature
ProteomicsLinkage Reprogramming by Tailor-made E3s Reveals Polyubiquitin Chain Requirements in DNA Damage Bypass
A polyubiquitin chain can adopt a variety of shapes, depending on how the ubiquitin monomers are joined. However, the relevance of linkage for the signaling functions of polyubiquitin chains is often poorly understood because of our inability to control or manipulate this parameter in vivo. Here we ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-04-25 | PXD030735 | Pride
Ubiquitin E3 ligase Dna damage bypass Pcna 
UnknownK29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.
Not available
S-EPMC4386640 | biostudies-literature
UnknownDiagnosing and mitigating method-based avidity artifacts that confound polyubiquitin-binding assays.
Not available
S-EPMC9680732 | biostudies-literature
UnknownBacterial ligases reveal fundamental principles of polyubiquitin specificity.
Not available
S-EPMC10872931 | biostudies-literature
UnknownMechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme.
Not available
S-EPMC4959314 | biostudies-literature
UnknownExploring the linkage dependence of polyubiquitin conformations using molecular modeling.
Not available
S-EPMC2813430 | biostudies-literature
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