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TranscriptomicsTranscription profiling of human patients with chronic kidney disease
Several reports have focused on the identification of biological elements involved in the development of abnormal systemic biochemical alterations in chronic kidney disease, but this abundant literature results most of the time fragmented. To better define the cellular machinery associated to this c...
ORGANISM(S): Homo sapiens 
2009-12-04 | E-GEOD-15072 | biostudies-arrayexpress
TranscriptomicsEffect of Mycophenolic Acid on renal transplant recipients
Mycophenolic acid (MPA), an immunosuppressive drug widely used in kidney transplantation, has been suggested to have anti-fibrotic effects. To analyze at a genomic level these effects, we prospectively studied a group of stable kidney transplant recipients (n=35) on cyclosporine (CyA) and azathiopri...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-14630 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of peripheral blood mononuclear cells before and after eradication of Hepatitis C virus by DAAs
Remarkable improvements in the treatment of HCV infection have been observed since the availability of HCV Direct-antiviral agents (DAAs). We evaluated by microarray the transcriptomic profile of circulating mononuclear cells from 8 chronic HCV patients at baseline and 12 weeks after the end of 4 w...
ORGANISM(S): Homo sapiens 
2023-07-31 | E-MTAB-10952 | biostudies-arrayexpress
TranscriptomicsAltered modulation of WNT-β-catenin and PI3K/Akt pathways in IgA nephropathy
To uncover new molecular mechanisms involved in IgAN pathogenesis, we compared the genomic profiles of 12 IgAN patients with 8 healthy subjects, We included addiotional disease controls 3 FSGS(Focal Segmenal glomerulosclerosis) patients and 3 membrano proliferative glomerulonephritis type I (MPGN-I)...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-14795 | biostudies-arrayexpress
TranscriptomicsMolecular characterization of chronic antibody mediated rejection in kidney transplantation (mRNA CD4)
Chronic antibody-mediated rejection (CAMR) represents the main cause of kidney graft loss, but its pathogenesis is unclear. In order to uncover the molecular mechanisms underlying this condition, we characterized the molecular signature of circulating peripheral blood mononuclear cells and, separate...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-64261 | biostudies-arrayexpress
TranscriptomicsPre-Transplant recipients’ clinical and immunological features are independently associated with the development of delayed graft function in kidney transplantation
Delayed graft function (DGF) is associated with a reduced graft survival. Donors' features have been always considered as key pathogenic factors in this setting. The aim of our study was to evaluate the role of recipients' characteristics in the development of DGF. We prospectively enrolled 932 kidn...
ORGANISM(S): Homo sapiens 
2022-12-22 | E-MTAB-10747 | biostudies-arrayexpress
TranscriptomicsMolecular characterization of chronic antibody mediated rejection in kidney transplantation (mRNA)
Chronic antibody-mediated rejection (CAMR) represents the main cause of kidney graft loss, but its pathogenesis is unclear. In order to uncover the molecular mechanisms underlying this condition, we characterized the molecular signature of circulating peripheral blood mononuclear cells and, separate...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-51675 | biostudies-arrayexpress
TranscriptomicsMolecular characterization of chronic antibody mediated rejection in kidney transplantation (microRNA)
Chronic antibody-mediated rejection (CAMR) represents the main cause of kidney graft loss, but its pathogenesis is unclear. In order to uncover the molecular mechanisms underlying this condition, we characterized the molecular signature of circulating peripheral blood mononuclear cells and, separate...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-51676 | biostudies-arrayexpress
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