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We have assessed the importance of SQSTM1 in human induced pluripotent stem cell (iPSC)-derived cortical neurons with and without SQSTM1. By combining high-content imaging, RNA-Seq, and functional mitochondrial readouts, we showed that SQSTM1 depletion causes aberrations in mitochondrial gene expres...
ORGANISM(S): Homo sapiens 
Profiling of circulating tumor DNA (ctDNA) may offer a non-invasive approach to monitor disease progression. Here, we developed a quantitative method, exploiting local tissue-specific cell-free DNA (cfDNA) degradation patterns, that accurately estimates ctDNA burden independent of genomic aberration...
This study looks at signatures of Aristolochic Acid mutagenesis in bladder cancer, based on exome and whole genome sequencing data. Thirteen bladder tumors and their matched normal DNAs were sequenced on Illumina platforms. Among them eleven were exome sequenced and two were whole genome sequenced.
WGS data of plasma samples from healthy individuals (N=29)
WGS data of plasma samples from BRCA patients (N=10)
WGS data of plasma samples from CRC patients (N=12)
WGS data of buffy coat from CRC patients
Data Access Committee EGAC00001001733
Data Access Committee EGAC00001000256
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