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TranscriptomicsGene expression profile in pelvic organ prolapse
Introduction and Hypothesis: Identify processes contributing to pelvic organ prolapse (POP) by transcriptional profiling of pelvic connective tissue in conjunction with light microscopy. Methods: We performed a frequency matched case-control study of women undergoing hysterectomy. Total RNA, extract...
ORGANISM(S): Homo sapiens 
2008-09-19 | E-GEOD-12852 | biostudies-arrayexpress
TranscriptomicsRegulation of histone methylation and gene expression reprogramming in rice inflorescence meristem
Rice inflorescence meristem (IM) development is critical for panicle size and grain production. The transition from SAM to IM is an important development stage in rice. Here we report the application of ChIP-seq technology for profiling of H3K4me3 and H3K27me3 modification in SAM, IM, SDG711 RNAi IM...
ORGANISM(S): Oryza sativa Japonica Group 
2015-05-14 | E-GEOD-68299 | biostudies-arrayexpress
TranscriptomicsComparative transcriptomics of geographic strains of catfishes exposed to chronic high temperatures
This study examined differentially expressed (DE) gene transcripts and regulated pathways of two geographically distinct channel catfish (Ictalurus punctatus) strains and one hybrid catfish (I. punctatus x [blue catfish] I. furcatus) strain to test whether one particular catfish type handled thermal...
ORGANISM(S): Ictalurus punctatus x Ictalurus furcatus 
2014-04-23 | E-GEOD-56982 | biostudies-arrayexpress
UnknownMycobacterium tuberculosis Prolyl Oligopeptidase Induces In vitro Secretion of Proinflammatory Cytokines by Peritoneal Macrophages.
Not available
S-EPMC5293833 | biostudies-literature
UnknownChemical and Biological Properties of Different Romanian Populations of Hyssopus officinalis Correlated via Molecular Docking.
Not available
S-EPMC11598396 | biostudies-literature
GenomicsA Novel HDAC Complex in the Control of Transcription and Genome Stability
The acetylation state of histones, controlled by histone acetyltransferases and deacetylases, profoundly affects DNA transcription and repair by modulating chromatin accessibility to the cellular machinery. The Schizosaccharomyces pombe HDAC Clr6 (human HDAC1) binds to different sets of proteins tha...
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-10 | E-GEOD-57040 | biostudies-arrayexpress
GenomicsMeiotic recombination cold spots in chromosomal cohesion sites [ChIP-Seq]
Meiotic chromosome architecture called M-bM-^@M-^\axis-loop structuresM-bM-^@M-^] and histone modifications have been demonstrated to regulate the Spo11-dependent formation of DNA double-strand breaks (DSBs) that trigger meiotic recombination. Using genome-wide chromatin immunoprecipitation (ChIP) a...
ORGANISM(S): Saccharomyces cerevisiae 
2014-03-31 | E-GEOD-52862 | biostudies-arrayexpress
TranscriptomicsCharacterization of human plasma-derived exosomal RNAs
Exosomes, endosome-derived membrane microvesicles, contain a specific set of RNA transcripts that are involved in cell-cell communication and hold a great potential as disease biomarkers. To systemically characterize exosomal RNA profiles, we performed RNA sequencing analysis using three human plasm...
ORGANISM(S): Homo sapiens 
2013-05-15 | E-GEOD-45722 | biostudies-arrayexpress
TranscriptomicsRNA-Seq profiling unveils a non-canonical Wnt signalling signature in pancreas versus liver fate decision
Understanding how distinct cell types arise from common multipotent progenitor cells is a major quest in stem cell biology. This knowledge will aid in the targeted differentiation and growth of stem cells, but also in the discovery of the basis of cellular plasticity and of how tissue programming ca...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-40823 | biostudies-arrayexpress
GenomicsChromatin-wide profiling of the protein kinase DYRK1A reveals a role as a transcriptional activator of cell growth related genes
DYRK1A is a dosage-sensitive protein kinase that fulfills key roles during development and in tissue homeostasis, and its dysregulation results in human pathologies. DYRK1A is present in both the nucleus and cytoplasm of mammalian cells, although its nuclear function remains unclear. Genome-wide ana...
ORGANISM(S): Homo sapiens 
2015-03-11 | E-GEOD-63712 | biostudies-arrayexpress
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