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TranscriptomicsGenome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP-arrays
We describe a method for automatic detection of absolute segmental copy numbers and genotype status in complex cancer genome profiles measured by SNP arrays. The method is based on pattern recognition of segmented and smoothed copy number and allelic imbalance profiles. Overall copy number assignmen...
ORGANISM(S): Homo sapiens 
2009-10-29 | E-GEOD-18799 | biostudies-arrayexpress
TranscriptomicsPolarity gene alterations in pure invasive micropapillary carcinomas of the breast
In this study we have identified a new morphological pattern in IMPC defined by the presence of numerous bi-nucleated cells, related to abnormal expression of genes involved in regulation of mitosis. We also demonstrated that IMPC presented tight and adherens junctions proteins expression...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-37035 | biostudies-arrayexpress
Genomics8044f1ed-f7ee-42e5-87e3-6506d5746d96 - samples
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Despite improvement of diagnosis and treatment of the primary tumor, there is no effective treatment of metastatic disease and approximately half of patients will die within one year or less following metastases detecti...
EGAD00001004554 | EGA
GenomicsComprehensive genetic analysis of uveal melanoma heterogeneity during metastatic progression
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Despite improvement of diagnosis and treatment of the primary tumor, there is no effective treatment of metastatic disease and approximately half of patients will die within one year or less following metastases detecti...
EGAS00001002761 | EGA
TranscriptomicsAnalysis of allele specific expression and its chromatin state to identify genes that are escaping X chromosome inactivation
Disappearance of the Barr body has long been considered a hallmark of cancer, although whether this corresponds to epigenetic instability and transcriptional reactivation, or to genetic loss, has remained unclear. Here we show that in breast cancer cell lines as well as primary breast tumors, the in...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-62966 | biostudies-arrayexpress
TranscriptomicsIdentification of SNPs using genomic DNA and allele specific expression using nascent RNA on snp6 array
Disappearance of the Barr body has long been considered a hallmark of cancer, although whether this corresponds to epigenetic instability and transcriptional reactivation, or to genetic loss, has remained unclear. Here we show that in breast cancer cell lines as well as primary breast tumors, the in...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-62965 | biostudies-arrayexpress
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