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TranscriptomicsWnt addiction of genetically defined cancers reversed by PORCN inhibition
Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors. Inhibition of Wnt secretion by blocking an essential post-translational modification, palmitoleation, provides a useful therapeutic intervention. Inh...
ORGANISM(S): Homo sapiens 
2015-08-12 | E-GEOD-69687 | biostudies-arrayexpress
UnknownDevelopment of a triazole class of highly potent Porcn inhibitors.
Not available
S-EPMC5142825 | biostudies-literature
TranscriptomicsTranscriptional response to PORCN inhibition using an in vivo model of RNF43 mutant pancreatic adenocarcinoma (HPAF-II) in EP300 knockout and WT cells 
RNF43-mutant pancreatic tumors are driven by Wnt signaling and sensitive to Wnt inhibition, e.g. PORCN inhibitors. However, some RNF43-mutant pancreatic cancers are intrinsically resistant to Wnt inhibition. We identified that EP300 mutations confer resistance to PORCN inhibitors in RNF43-mutant pan...
ORGANISM(S): Homo sapiens 
2022-06-16 | GSE183893 | GEO
UnknownPORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers.
Not available
S-EPMC10200719 | biostudies-literature
UnknownStereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN).
Not available
S-EPMC6484125 | biostudies-literature
GenomicsTranscriptional response to PORCN inhibition using an in vivo model of RNF43 mutant pancreatic adenocarcinoma (HPAF-II) in EP300 knockout and WT cells
Transcriptional response to PORCN inhibition using an in vivo model of RNF43 mutant pancreatic adenocarcinoma (HPAF-II) in EP300 knockout and WT cells
PRJNA762294 | ENA
UnknownSelective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling.
Not available
S-EPMC6004566 | biostudies-literature
Unknown<i>In vitro</i> reconstitution of Wnt acylation reveals structural determinants of substrate recognition by the acyltransferase human Porcupine.
Not available
S-EPMC6322882 | biostudies-literature
UnknownStructural basis for Porcupine inhibition.
Not available
S-EPMC12612157 | biostudies-literature
TranscriptomicsCUT&RUN LoV-U time-course profiling of Wnt transcriptional complex in ΔCTNNB1 HEK293T cells compared to wild-type
Wnt/β-catenin signaling is commonly understood to activate transcription through pre-accessible regulatory elements. To investigate whether this pathway also directly modulates chromatin states, we performed CUT&RUN in human embryonic kidney 293T (HEK293T) and matched ΔCTNNB1 cells to profile β-cate...
ORGANISM(S): Homo sapiens 
2026-06-27 | E-MTAB-17186 | biostudies-arrayexpress
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