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TranscriptomicsTranscription profiling of superior mesenteric arteries from rats that have had portal vein ligation or a sham procedure for different lengths of time
Twenty-four male Sprague-Dawley rats were used for this experiment, a partial portal vein ligadure (PVL) was carried out in 12 rats, the other 12 rats were sham-operated. Superior mesenteric artery (SMA) samples were sequentially obtained from 2 rats from the PVL and sham groups at 1, 6, and 24 hour...
ORGANISM(S): Rattus norvegicus 
2008-05-09 | E-MEXP-1107 | biostudies-arrayexpress
TranscriptomicsThe regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure.
Following parenchymal loss, the liver regenerates restoring normal mass and metabolic function. Prevailing theories on triggering events leading to regeneration include humoral, metabolic and flow-mediated mechanisms, the latter emphasizing the importance of shear stress mediated nitric oxide (NO) r...
ORGANISM(S): Sus scrofa 
2008-01-14 | E-GEOD-6860 | biostudies-arrayexpress
TranscriptomicsA cell atlas of the regenerating human liver after portal vein embolization
In this work, we applied single-cell transcriptome sequencing on primary human liver tissue samples to study cellular processes underlying human liver regeneration. In order to study regeneration-specific cellular processes we obtained primary healthy liver tissue samples and liver tissue samples fr...
ORGANISM(S): Homo sapiens 
2024-04-13 | E-MTAB-12594 | biostudies-arrayexpress
MetabolomicsMetabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor (Untargeted urine UPLC-MS assay)
BACKGROUND: Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated the metabolic effects of pesticides using individual molecules, often at non relevant doses or in combination with other r...
2019-05-28 | MTBLS596 | MetaboLights
MetabolomicsProteolethargy is a pathogenic mechanism in chronic disease

The pathogenic mechanisms of many diseases are well understood at the molecular level, but there are prevalent diseases associated with pathogenic signaling, such as diabetes and chronic inflammatory disorders, where our understanding is more limited. Here we report that pathogenic signaling supp...

2024-08-09 | MTBLS9535 | MetaboLights
TranscriptomicsTranscriptomic signatures of progressive and regressive liver fibrosis and portal hypertension
Persistent liver injury triggers a fibrogenic program that causes pathologic remodelling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension. The dynamics of gene regulation during liver disease progression and regression remain understudied. Here, we generated hepatic tra...
ORGANISM(S): Mus musculus 
2024-02-13 | E-MTAB-13804 | biostudies-arrayexpress
MetabolomicsEndoplasmic reticulum-derived bodies enable a single-cell chemical defense in Brassicaceae plants
Brassicaceae plants have a dual-cell type of chemical defense against herbivory. Here we show a novel single-cell defense involving endoplasmic reticulum (ER)-derived organelles (ER bodies) and the vacuoles. We identify various glucosinolates as endogenous substrates of the ER-body β-glucosidases BG...
2020-02-04 | MTBLS1383 | MetaboLights
MetabolomicsWashed Microbiota Transplantation for Overt Hepatic Encephalopathy: A Feasibility Pilot Study
Objective:Washed microbiota transplantation may modulate the gut-liver-brain axis in hepatic encephalopathy (HE). Evidence in overt HE (OHE) remains limited, and previous trials have enrolled patients in remission rather than during an active episode. Methods:In this prospective, non-randomized pilo...
2026-07-21 | MTBLS15106 | MetaboLights
ProteomicsProteomic profile in the diagnostics of portal hypertension in patients with compensated advanced liver disease
Study aim: To compare proteomic profiles of patients with compensated advanced liver disease with and without clinically significant portal hypertension (CSPH) and by analyzing differently expressed proteins to identify potential new serum biomarkers for the early diagnosis of CSPH. Subjects and met...
ORGANISM(S): Homo sapiens (Human) 
2024-02-01 | PXD040807 | Pride
Proteomics Biological markers Liver cirrhosis Portal hypertension 
MetabolomicsDynamic utilization of low-molecular-weight organic substrates across a microbial growth rate gradient

AIM: Low-molecular-weight organic substances (LMWOSs) are at the nexus between micro-organisms, plant roots, detritus and the soil mineral matrix. The nominal oxidation state of carbon (NOSC) has been suggested as a potential parameter for modelling microbial uptake rates of LMWO...

2023-08-14 | MTBLS3558 | MetaboLights
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